Indications And Dose
Urinary frequency | Urinary urgency | Urinary incontinence ▶BY MOUTH ▶Adult: 5 mg once daily, increased if necessary to 10 mg once daily
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Drug reference
Urinary frequency | Urinary urgency | Urinary incontinence ▶BY MOUTH ▶Adult: 5 mg once daily, increased if necessary to 10 mg once daily
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DUE TO INTERACTIONS ▶Manufacturer advises max. dose 5 mg daily with concurrent use of potent inhibitors of CYP3A4; avoid concurrent use in patients who also have moderate hepatic impairment or severe renal impairment.
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Neurogenic bladder disorder. susceptibility to QT-interval prolongation
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The need for continuing therapy for urinary incontinence should be reviewed every 4–6 weeks until symptoms stabilise, and then every 6–12 months.
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→Appendix 1: solifenacin
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▶Common or very common Gastrointestinal discomfort ▶Uncommon Cystitis. dry eye. dry throat. fatigue. gastrointestinal disorders. nasal dryness. peripheral oedema. taste altered. urinary tract infection ▶Rare or very rare Hallucination ▶Frequency not known Anaphylactic reaction. appetite decreased. arrhythmias. delirium. dysphonia. glaucoma. hyperkalaemia. liver disorder. muscle weakness. QT interval prolongation. renal impairment
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Manufacturer advises caution—no information available.
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Manufacturer advises avoid—present in milk in animal studies.
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Manufacturer advises caution in moderate impairment (risk of increased half-life); avoid in severe impairment (no information available). Dose adjustments Manufacturer advises maximum 5 mg daily in moderate impairment.
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Dose adjustments Max. 5 mg daily if eGFR less than 30 mL/minute/1.73 m2.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Oral solution ▶Solifenacin succinate (Non-proprietary) Solifenacin succinate 1 mg per 1 ml Solifenacin 5mg/5ml oral solution sugar free sugar-free | 150 ml P £22.50 Oral suspension ▶Vesicare (Astellas Pharma Ltd) Solifenacin succinate 1 mg per 1 ml Vesicare 1mg/ml oral suspension sugar-free | 150 ml P £27.62 DT = £27.62 Genito-urinary system Tablet CAUTIONARY AND ADVISORY LABELS 3 ▶Solifenacin succinate (Non-proprietary) Solifenacin succinate 5 mg Solifenacin 5mg tablets | 30 tablet P £27.62 DT = £3.54 | 250 tablet P £29.50–£230.17 Solifenacin succinate 10 mg Solifenacin 10mg tablets | 30 tablet P £35.91 DT = £4.48 | 100 tablet P £119.70 | 250 tablet P £45.99–£299.25 ▶Vesicare (Astellas Pharma Ltd) Solifenacin succinate 5 mg Vesicare 5mg tablets | 30 tablet P £27.62 DT = £3.54 Solifenacin succinate 10 mg Vesicare 10mg tablets | 30 tablet P £35.91 DT = £4.48 eiiii F 820
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5 mg once daily, increased if necessary to 10 mg
First-line fragment. Read the complete Indications and Dose section above.
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