Therapeutic Action
Potassium-sparing diuretic, antagonist of aldosterone
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Drug reference
Potassium-sparing diuretic, antagonist of aldosterone
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Oedema associated with heart failure, hepatic cirrhosis and nephrotic syndrome
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Do not administer to patients with severe renal impairment, anuria, hyperkalaemia > 5 mmol/litre, hyponatraemia. Do not combine with potassium salts, potassium-sparing diuretics; lithium (risk of lithium toxicity). Avoid or closely monitor combination with angiotensin-converting enzyme inhibitors (risk of severe, potentially fatal hyperkalaemia), digoxin (risk of digoxin toxicity) and reduce dosages. May cause: hyperkalaemia (especially in elderly or diabetics patients, patients with renal impairment or patients taking NSAIDs), hyponatraemia; metabolic acidosis (in patients with decompensated cirrhosis); gynecomastia, metrorrhagia, impotence, amenorrhoea, gastrointestinal disturbances, headache, skin rash, drowsiness. Administer with caution in patients with hepatic or renal impairment or diabetes. Monitor regularly plasma-potassium levels. Pregnancy: avoid, use only if clearly needed (risk of feminisation of foetus); spironolactone is not indicated in the treatment of pregnancy-related oedema. Breast-feeding: no contra-indication
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25 mg tablet
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Adjunctive therapy in heart failure Adult: 25 mg once daily Ascites in hepatic cirrhosis Adult: 100 to 400 mg daily. When weight is stable, administer the lowest possible maintenance dose, in order to prevent adverse effects. Oedema in nephrotic syndrome Adult: 100 to 200 mg daily The daily dose can be administered in 2 to 3 divided doses or once daily.
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According to clinical response; avoid prolonged use.
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In children with oedema, the daily dose is 1 to 3 mg/kg once daily or 0.5 to 1.5 mg/kg 2 times daily. Spironolactone is also used for the diagnosis and treatment of primary hyperaldosteronism.
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– Below 25 °C
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25 mg once daily
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100 to 400 mg daily.
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100 to 200 mg daily
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