Therapeutic Action
Antibacterial (group of aminoglycosides)
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Drug reference
Antibacterial (group of aminoglycosides)
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Alternative to gentamicin in plague Brucellosis, in combination with doxycycline
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Do not administer in patients with allergy to aminoglycosides. Administer with caution to patients with history of renal, vestibular or auditory problems. Reduce the dose in patients with renal impairment. May cause: irreversible ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade; rarely, allergic reactions. Stop treatment in the event of dizziness, tinnitus or hearing loss (ototoxicity). Drink sufficient liquid to limit the risk of renal toxicity. Do not combine with another aminoglycoside. Avoid or monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers (increased neuromuscular blockage). Pregnancy: CONTRA-INDICATED Breast-feeding: no contra-indication
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Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 3.2 ml of water for injection to obtain a 250 mg/ml solution, for IM injection. DO NOT ADMINISTER BY IV INJECTION.
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Plague Child: 15 mg/kg (max. 1 g) every 12 hours Adult: 1 g every 12 hours Brucellosis Adult: 1 g once daily
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Plague: 10 to 14 days Brucellosis: 2 weeks
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– Below 25 °C
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15 mg/kg (max. 1 g) every 12 hours
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