Drug Action
Strontium ranelate stimulates bone formation and reduces bone resorption.
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Drug reference
Strontium ranelate stimulates bone formation and reduces bone resorption.
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Severe osteoporosis in men and postmenopausal women at increased risk of fractures [when other treatments are contra-indicated or not tolerated] ▶BY MOUTH ▶Adult: 2 g daily, dose to be taken in water and at bedtime
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Cerebrovascular disease. current or previous venous thromboembolic event. ischaemic heart disease. peripheral arterial disease. temporary or permanent immobilisation. uncontrolled hypertension
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Risk factors for cardiovascular disease—assess before and every 6–12 months during treatment. Risk factors for venous thromboembolism (discontinue in patients who become immobile)
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→Appendix 1: strontium
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▶Common or very common Angioedema. arthralgia. bronchial hyperreactivity. consciousness impaired. constipation. diarrhoea. dizziness. embolism and thrombosis. gastrointestinal discomfort. gastrointestinal disorders. headache. hepatitis. hypercholesterolaemia. insomnia. memory loss. muscle complaints. myocardial infarction. nausea. pain. paraesthesia. peripheral oedema . skin reactions. vertigo. vomiting ▶Uncommon Alopecia. confusion. dry mouth. fever. lymphadenopathy. malaise. oral disorders. seizure ▶Rare or very rare Bone marrow failure. eosinophilia. severe cutaneous adverse reactions (SCARs)
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Manufacturer advises avoid—toxicity in animal studies.
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Manufacturer advises avoid—data suggest present in human milk.
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Manufacturer advises avoid if creatinine clearance less than 30 mL/minute. l EFFECT ON LABORATORY TESTS Manufacturer advises may interfere with colorimetric assay of calcium in blood and urine—consult product literature. Endocrine system
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Granules should be stirred into at least 30mL of water, and taken immediately at bedtime on an empty stomach; avoid food for at least 2 hours before treatment, particularly calcium-containing products e.g. milk.
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There can be variation in the licensing of different medicines containing the same drug. Granules EXCIPIENTS: May contain Aspartame A ▶Strontium ranelate (non-proprietary) Strontium ranelate 2 gram Strontium ranelate 2g granules sachets sugar free sugar-free | 28 sachet P £149.91 DT = £149.91 CALCIUM REGULATING DRUGS › PARATHYROID HORMONES AND ANALOGUES
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Patients or carers should be given advice on how to administer strontium ranelate granules. Severe allergic reactions Patients should be advised to stop taking strontium ranelate and consult their doctor immediately if skin rash develops.
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2 g daily, dose to be taken in water and at
First-line fragment. Read the complete Indications and Dose section above.
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