Therapeutic Action
Sulfonamide antibacterial
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Drug reference
Sulfonamide antibacterial
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Treatment and secondary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with pyrimethamine
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Do not administer to sulfonamide-allergic patients; patients with severe renal or hepatic impairment. May cause: gastrointestinal disturbances, renal disorders (crystalluria, etc.), photosensitivity, megaloblastic anaemia due to folic acid deficiency; haemolytic anaemia in patients with G6PD deficiency; allergic reactions (fever, rash, etc.) sometimes severe (Lyell's and Stevens-Johnson syndromes, haematological disorders, etc.). In these cases, stop treatment immediately. Adverse effects occur more frequently in patients with HIV infection. Monitor blood count if possible. Reduce the dose by half in patients with renal impairment. Do not combine with methotrexate and phenytoin. Administer calcium folinate systematically to prevent folic acid deficiency. Drink a lot of liquid during treatment. Pregnancy: no contra-indication. However, avoid using during the last month of pregnancy (risk of jaundice and haemolytic anaemia in the newborn infant). Breast-feeding: avoid if preterm infant, jaundice, low-birth weight, infant under one month of age. If sulfadiazine is used, observe the infant for signs of jaundice.
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500 mg tablet
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Treatment of toxoplasmosis Adult: 2 g 2 to 3 times daily for 6 weeks minimum Secondary prophylaxis of toxoplasmosis Adult: 1 to 1.5 g 2 times daily, as long as necessary
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– Below 25 °C
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2 g 2 to 3 times daily for 6 weeks minimum
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1 to 1.5 g 2 times daily, as long as necessary
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