Drug reference
Plaque psoriasis ▶TO THE SKIN ▶Adult: Apply once daily, preferably at bedtime, maximum 10 g ointment or 10 mL lotion daily, when lotion and ointment used together, maximum total tacalcitol 280 micrograms in any one week (e.g. lotion 30 mL with ointment 40 g)
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Calcium metabolism disorders
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Avoid eyes. erythrodermic exfoliative psoriasis (enhanced risk of hypercalcaemia). generalised pustular psoriasis (enhanced risk of hypercalcaemia). if used in conjunction with UV treatment CAUTIONS, FURTHER INFORMATION ▶UV treatment If tacalcitol is used in conjunction with UV treatment, UV radiation should be given in the morning and tacalcitol applied at bedtime.
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→Appendix 1: vitamin D substances
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▶Uncommon Skin reactions ▶Frequency not known Hypercalcaemia
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Manufacturer advises avoid unless no safer alternative—no information available.
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Manufacturer advises avoid application to breast area; no information available on presence in milk.
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Monitor serum calcium if risk of hypercalcaemia.
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There can be variation in the licensing of different medicines containing the same drug. Ointment ▶Curatoderm (Almirall Ltd) Tacalcitol (as Tacalcitol monohydrate) 4 microgram per 1 gram Curatoderm 4micrograms/g ointment | 30 gram P £13.40 DT = £13.40 | 100 gram P £30.86 DT = £30.86 Liquid EXCIPIENTS: May contain Disodium edetate, propylene glycol ▶Curatoderm (Almirall Ltd) Tacalcitol (as Tacalcitol monohydrate) 4 microgram per 1 gram Curatoderm 4micrograms/g lotion | 30 ml P £12.73 DT = £12.73 Perspiration Skin 4.1 Hyperhidrosis Hyperhidrosis Overview Aluminium chloride hexahydrate p. 1332 is a potent antiperspirant used in the treatment of hyperhidrosis. Aluminium salts are also incorporated in preparations used for minor fungal skin infections associated with hyperhidrosis. Limited evidence suggests that oxybutynin hydrochloride p. 821 [unlicensed indication] can be used to treat hyperhidrosis in patients whose symptoms are not adequately managed through lifestyle modifications and antiperspirants. In more severe cases specialists use glycopyrronium bromide p. 1331 as a 0.05% solution in the iontophoretic treatment of hyperhidrosis of plantar and palmar areas. Botox ® contains botulinum toxin type A complex p. 425 and is licensed for use intradermally for severe hyperhidrosis of the axillae unresponsive to topical antiperspirant or other antihidrotic treatment. ANTIMUSCARINICS eiiii F 820
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Hands should be washed thoroughly after application to avoid inadvertent transfer to other body areas.
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Apply once daily, preferably at bedtime,
First-line fragment. Read the complete Indications and Dose section above.
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