Drug reference
Septicaemia | Urinary-tract infections | Lower respiratory- tract infections caused by susceptible Gram-negative bacteria ▶BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 2 g every 12 hours, alternatively 2 g every 8 hours, higher daily dose to be used in critically ill patients ▶BY CONTINUOUS INTRAVENOUS INFUSION ▶Adult: (consult product literature)
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Accumulation of sodium from injection can occur with high doses
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→Appendix 1: penicillins
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Arthralgia. fever. myalgia. nervous system disorder. thrombophlebitis
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Not known to be harmful.
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Trace amounts in milk.
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Accumulation of sodium from injection can occur in patients with renal failure. Dose adjustments Manufacturer advises reduce usual dose to 1 g every 12 hours if creatinine clearance Infection 30–60 mL/minute; reduce usual dose to 1 g every 24 hours if creatinine clearance 10–30 mL/minute; reduce usual dose to 1 g every 48 hours or 500 mg every 24 hours if creatinine clearance less than 10 mL/minute; no information available to recommend dose adjustments with higher daily dose for use in critically ill patients. l EFFECT ON LABORATORY TESTS False-positive urinary glucose (if tested for reducing substances).
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Manufacturer advises for intramuscular injection, reconstitute 1 g with 2 mL water for injections or Sodium chloride 0.9% (or 0.5 or 1% lidocaine solution, if pain is experienced at injection site). Manufacturer advises for slow intravenous injection, reconstitute 1 g with 10 mL water for injections or Sodium chloride 0.9%; give over 3–4 minutes. Manufacturer advises for intermittent intravenous infusion, give in Glucose 5% or 10% or Sodium chloride 0.9% or Ringer’s solution or Lactated Ringer’s solution. Reconstitute 1 g with 10 mL water for injections or infusion fluid, then dilute in up to 150 mL infusion fluid; give over 30–40 minutes. For continuous intravenous infusion, consult product literature.
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There can be variation in the licensing of different medicines containing the same drug. Powder for solution for injection ELECTROLYTES: May contain Sodium ▶Negaban (Eumedica Pharmaceuticals) Temocillin (as Temocillin sodium) 1 gram Negaban 1g powder for solution for injection vials | 1 vial P £25.45 DT = £25.45 (Hospital only) ANTIBACTERIALS › POLYMYXINS
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2 g every 12 hours, alternatively 2 g every
First-line fragment. Read the complete Indications and Dose section above.
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(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
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