Names and pronunciation
(tem-sir-oh′li-mus) Torisel
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Drug reference
(tem-sir-oh′li-mus) Torisel
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Func. class.: Antineoplastic
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Chem. class.: Kinase inhibitor, mTOR antagonist
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USES: Renal cell carcinoma
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CONTRAINDICATIONS: Preg- nancy, breastfeeding; hypersensitivity to this product or to sirolimus; polysorbate 80 Precautions: Children <13 yr, females, severe pulmonary/renal/hepatic disease (bilirubin >1-1.5 × ULN or AST >ULN but bilirubin ≤ULN), diabetes mellitus, hyperka- lemia, hyperuricemia, hypertension, bone marrow suppression, hypertriglyceridemia/ hyperlipidemia, surgery, brain tumors
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DOSAGE AND ROUTES • Adult: IV 25 mg over 30-60 min weekly; treat until disease progression or severe toxicity occurs Hepatic dose • Adult: IV (mild impairment) bilirubin >1-1.5×ULN or AST >ULN but bilirubin ≤ULN: reduce to 15 mg/wk; moderate or severe impairment, do not use
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Available forms: Solution (IV) 25 mg/mL
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• Adult: IV 25 mg over 30-60 min weekly; treat until disease progression or severe toxicity occurs Hepatic dose
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• Adult: IV (mild impairment) bilirubin >1-1.5×ULN or AST >ULN but bilirubin ≤ULN: reduce to 15 mg/wk; moderate or severe impairment, do not use
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