Drug reference
Mild to moderate hypertension ▶BY MOUTH ▶Adult: 1 mg daily for 7 days, then increased if necessary to 2 mg daily, dose should be taken at bedtime; maintenance 2–10 mg once daily, doses above 20 mg rarely improve efficacy Benign prostatic hyperplasia ▶BY MOUTH ▶Adult: Initially 1 mg daily, dose should be taken at bedtime, if necessary dose may be doubled at intervals of 1–2 weeks according to response; maintenance 5–10 mg daily; maximum 10 mg per day
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History of micturition syncope (in benign prostatic hyperplasia). history of postural hypotension (in benign prostatic hyperplasia)
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Cataract surgery (risk of intra-operative floppy iris syndrome). elderly. first dose CAUTIONS, FURTHER INFORMATION ▶First dose First dose may cause collapse due to hypotension within 30–90 minutes, therefore should be taken on retiring to bed; may also occur with rapid dose increase. ▶Elderly For alpha1-selective adrenoceptor blockers, prescription potentially inappropriate (STOPP criteria): . in those with symptomatic orthostatic hypotension or micturition syncope (risk of precipitating recurrent syncope) . in those with persistent postural hypotension i.e. recurrent drop in systolic blood pressure 20 mmHg (risk of syncope and falls). See also Prescribing in the elderly p. 33.
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→Appendix 1: alpha blockers
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Angioedema. anxiety. arrhythmias. arthritis. asthenia. chest pain. conjunctivitis. constipation. cough. depression. diarrhoea. dizziness. drowsiness. dry mouth. dyspnoea. epistaxis. fever. flatulence. gastrointestinal discomfort. gout. headache. hyperhidrosis. increased risk of infection. insomnia. joint Genito-urinary system disorders. myalgia. nasal congestion. nausea. oedema. pain. palpitations. paraesthesia. postural hypotension. sexual dysfunction. skin reactions. syncope. thrombocytopenia. tinnitus. urinary disorders. vasodilation. vertigo. vision disorders. vomiting. weight increased
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No evidence of teratogenicity; manufacturers advise use only when potential benefit outweighs risk.
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No information available.
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There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Terazosin (Non-proprietary) Terazosin (as Terazosin hydrochloride) 2 mg Terazosin 2mg tablets | 28 tablet P £2.70 DT = £2.20 Terazosin (as Terazosin hydrochloride) 5 mg Terazosin 5mg tablets | 28 tablet P £4.13 DT = £2.45 Terazosin (as Terazosin hydrochloride) 10 mg Terazosin 10mg tablets | 28 tablet P £8.11 DT = £8.05 ▶Hytrin (Advanz Pharma) Hytrin BPH tablets starter pack | 28 tablet P £10.97 Hytrin tablets starter pack | 28 tablet P £13.00 Terazosin (as Terazosin hydrochloride) 1 mg Hytrin 1mg tablets | 7 tablet P s Terazosin (as Terazosin hydrochloride) 2 mg Hytrin 2mg tablets | 28 tablet P £2.20 DT = £2.20 Terazosin (as Terazosin hydrochloride) 5 mg Hytrin 5mg tablets | 28 tablet P £4.13 DT = £2.45 Terazosin (as Terazosin hydrochloride) 10 mg Hytrin 10mg tablets | 28 tablet P £7.87 DT = £8.05 CHOLINE ESTERS
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Patient counselling is advised for terazosin tablets (initial dose). First dose effect First dose may cause collapse due to hypotensive effect (therefore should be taken on retiring to bed). Patient should be warned to lie down if symptoms such as dizziness, fatigue or sweating develop, and to remain lying down until they abate completely. Driving and skilled tasks May affect performance of skilled tasks e.g. driving.
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1 mg daily for 7 days, then increased if necessary
First-line fragment. Read the complete Indications and Dose section above.
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Initially 1 mg daily, dose should be taken at
First-line fragment. Read the complete Indications and Dose section above.
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