Drug reference
Movement disorders due to Huntington’s chorea, hemiballismus, senile chorea, and related neurological conditions ▶BY MOUTH ▶Adult: Initially 25 mg 3 times a day, then increased, if tolerated, in steps of 25 mg every 3–4 days; maximum 200 mg per day ▶Elderly: Lower initial dose may be necessary Moderate to severe tardive dyskinesia ▶BY MOUTH ▶Adult: Initially 12.5 mg daily, dose to be gradually increased according to response
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Depression. parkinsonism. phaeochromocytoma. prolactin-dependent tumours
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Susceptibility to QT-interval prolongation
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→Appendix 1: tetrabenazine
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▶Common or very common Anxiety. confusion. constipation . depression. diarrhoea. drowsiness. hypotension. insomnia. nausea. parkinsonism. vomiting ▶Uncommon Consciousness impaired. hyperthermia ▶Rare or very rare Neuroleptic malignant syndrome. skeletal muscle damage ▶Frequency not known Bradycardia. dizziness. dry mouth. epigastric pain. suicidal ideation
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Avoid unless essential—toxicity in animal studies.
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Avoid.
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Manufacturer advises caution (increased risk of exposure), particularly in severe impairment (no information available). Dose adjustments Manufacturer advises initial dose reduction of 50% and slower dose titration in mild to moderate impairment.
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Use with caution. Nervous system
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension Tablet CAUTIONARY AND ADVISORY LABELS 2 ▶Tetrabenazine (Non-proprietary) Tetrabenazine 25 mg Tetrabenazine 25mg tablets | 112 tablet P £107.69 DT = £107.69 ▶Tardiben (AOP Orphan Pharmaceuticals AG) Tetrabenazine 25 mg Tardiben 25mg tablets | 112 tablet P £100.00 DT = £107.69 ▶Xenazine (Alliance Pharmaceuticals Ltd) Tetrabenazine 25 mg Xenazine 25 tablets | 112 tablet P £100.00 DT = £107.69 MUSCLE RELAXANTS › PERIPHERALLY ACTING › NEUROTOXINS (BOTULINUM TOXINS)
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Avoid abrupt withdrawal.
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Driving and skilled tasks May affect performance of skilled tasks (e.g. driving).
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Initially 25 mg 3 times a day, then increased, if
First-line fragment. Read the complete Indications and Dose section above.
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Lower initial dose may be necessary
First-line fragment. Read the complete Indications and Dose section above.
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Initially 12.5 mg daily, dose to be gradually
First-line fragment. Read the complete Indications and Dose section above.
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