Indications And Dose
Mild deficiency ▶BY MOUTH ▶Adult: 25–100 mg daily Severe deficiency ▶BY MOUTH ▶Adult: 200–300 mg daily in divided doses
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Drug reference
Mild deficiency ▶BY MOUTH ▶Adult: 25–100 mg daily Severe deficiency ▶BY MOUTH ▶Adult: 200–300 mg daily in divided doses
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MHRA/CHM ADVICE (SEPTEMBER 2007) Although potentially serious allergic adverse reactions may rarely occur during, or shortly after, parenteral administration, the CHM has recommended that: . This should not preclude the use of parenteral thiamine in patients where this route of administration is required, particularly in patients at risk of Wernicke-Korsakoff syndrome where treatment with thiamine is essential; . Intravenous administration should be by infusion over 30 minutes; . Facilities for treating anaphylaxis (including resuscitation facilities) should be available when parenteral thiamine is administered.
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Severely thiamine-deficient mothers should avoid breast-feeding as toxic methyl-glyoxal present in milk.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Modified-release tablet ▶Thiamine (Non-proprietary) Thiamine hydrochloride 100 mg Vitamin B1 100mg modified- Blood and nutrition release tablets | 90 tablet £4.46 Tablet ▶Thiamine (Non-proprietary) Thiamine hydrochloride 25 mg Vitamin B1 25mg tablets | 100 tablet p s Thiamine hydrochloride 50 mg Thiamine 50mg tablets | 28 tablet p £1.22–£1.80 | 100 tablet p £6.72 DT = £4.35 Thiamine hydrochloride 100 mg Thiamine 100mg tablets | 28 tablet p £1.63–£6.72 | 100 tablet p £11.55 DT = £5.83 ▶Benerva (Teofarma) Thiamine hydrochloride 50 mg Benerva 50mg tablets | 100 tablet p £4.00 DT = £4.35 Thiamine hydrochloride 100 mg Benerva 100mg tablets | 100 tablet p £6.29 DT = £5.83
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25–100 mg daily
First-line fragment. Read the complete Indications and Dose section above.
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200–300 mg daily in divided doses
First-line fragment. Read the complete Indications and Dose section above.
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