Drug reference
Conditioning treatment before haematopoietic stem cell transplantation in the treatment of haematological disease or solid tumours, in combination with other chemotherapy ▶BY INTRAVENOUS INFUSION ▶Adult: (consult local protocol)
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Avoid in Acute porphyrias p. 1120
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Scottish Medicines Consortium (SMC) decisions SMC No. 790/12 The Scottish Medicines Consortium has advised (June 2012) that thiotepa (Tepadina ®) is not recommended for use within NHS Scotland in combination with other chemotherapy as conditioning treatment in adults or children with haematological diseases, or solid tumours prior to haematopoietic stem cell transplantation.
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→Appendix 1: alkylating agents
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▶Common or very common Alopecia. amenorrhoea. anaemia. anxiety. appetite decreased. arrhythmias. arthralgia. asthenia. azoospermia. cataract. chills. cognitive disorder. confusion. conjunctivitis. constipation. cough. cystitis. delirium. diarrhoea. dizziness. dysuria. embolism. encephalopathy. extrapyramidal symptoms. fever. gastrointestinal discomfort. gastrointestinal disorders. generalised oedema. graft versus host disease. haemorrhage. headache. hearing impairment. heart failure. hepatic disorders. hyperglycaemia. hypersensitivity. hypertension. hypopituitarism. increased risk of infection Immune system and malignant disease . infertility. intracranial aneurysm. intracranial haemorrhage. leucopenia. lymphoedema. menopausal symptoms. mucositis. multi organ failure. myalgia. nausea. neutropenia. ototoxicity. pain. pancytopenia. paraesthesia. psychiatric disorder. pulmonary oedema. renal impairment. respiratory disorders. secondary malignancy. seizure. sepsis. sinusoidal obstruction syndrome. skin reactions. stomatitis. thrombocytopenia. toxic shock syndrome. vision blurred. vomiting. weight increased ▶Uncommon Cardiomyopathy. hallucination. hypoxia. myocarditis ▶Frequency not known Severe cutaneous adverse reactions (SCARs)
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Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Avoid (teratogenic and embryotoxic in animals). See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Discontinue breast-feeding.
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There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ▶Tepadina (Adienne Pharma & Biotech) Thiotepa 15 mg Tepadina 15mg powder for concentrate for solution for infusion vials | 1 vial P s Thiotepa 100 mg Tepadina 100mg powder for concentrate for solution for infusion vials | 1 vial P s
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(consult local protocol)
First-line fragment. Read the complete Indications and Dose section above.
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