Drug reference
Infections due to Pseudomonas and Proteus spp. ▶BY INTRAVENOUS INFUSION ▶Adult: 3.2 g every 6–8 hours; increased if necessary to 3.2 g every 4 hours, increased frequency used for more severe infections
PDF page 598
High doses may lead to hypernatraemia (owing to sodium content of preparations)
PDF page 598
Dose is expressed as a combination of ticarcillin (as sodium salt) and clavulanic acid (as potassium salt) in a ratio of 15:1.
PDF page 598
→Appendix 1: clavulanate. penicillins
PDF page 598
Eosinophilia. haemorrhage. hypokalaemia . thrombophlebitis
PDF page 598
Not known to be harmful.
PDF page 598
Trace amounts in milk, but appropriate to use.
PDF page 598
Manufacturer advises caution in severe impairment.
PDF page 598
Accumulation of electrolytes contained in preparation can occur in patients with renal failure. Dose adjustments Reduce dose to 3.2 g every eight hours if eGFR 30–60 mL/minute/1.73 m2; 1.6 g every eight hours if eGFR 10–30 mL/minute/1.73 m2; 1.6 g every twelve hours if eGFR less than 10 mL/minute/1.73 m2. l EFFECT ON LABORATORY TESTS False-positive urinary glucose (if tested for reducing substances).
PDF page 598
For intravenous infusion (Timentin ®), give intermittently in Glucose 5%. Suggested volume (depending on dose) 100–150 mL; give over 30–40 minutes.
PDF page 598
There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ELECTROLYTES: May contain Potassium, sodium ▶Timentin (GlaxoSmithKline UK Ltd) Clavulanic acid (as Potassium clavulanate) 200 mg,Ticarcillin (as Ticarcillin sodium) 3 gram Timentin 3.2g powder for solution for infusion vials | 4 vial P £21.32 ANTIBACTERIALS › PENICILLINS, BETA- LACTAMASE SENSITIVE eiiii F 575
PDF pages 598, 599
3.2 g every 6–8 hours; increased if necessary to
First-line fragment. Read the complete Indications and Dose section above.
PDF page 598
