Drug reference
Urinary frequency | Urinary urgency | Urinary incontinence ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 2 mg twice daily, reduced if not tolerated to 1 mg twice daily ▶BY MOUTH USING MODIFIED-RELEASE CAPSULES ▶Adult: 4 mg once daily
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History of QT-interval prolongation
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The need for continuing therapy for urinary incontinence should be reviewed every 4–6 weeks until symptoms stabilise, and then every 6–12 months.
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→Appendix 1: tolterodine
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▶Common or very common Abdominal pain. bronchitis. chest pain. diarrhoea. dry eye. fatigue. gastrointestinal disorders. paraesthesia. peripheral oedema. vertigo. weight increased ▶Uncommon Arrhythmia. heart failure. memory loss. nervousness ▶Frequency not known Hallucination
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Manufacturer advises avoid—toxicity in animal studies.
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Manufacturer advises avoid—no information available.
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Manufacturer advises caution (risk of increased exposure). Dose adjustments For immediate-release medicines, manufacturer advises dose reduction to 1 mg twice daily. For modified-release capsules, manufacturer advises dose reduction to 2 mg once daily.
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Manufacturer advises caution (risk of increased exposure) Dose adjustments For immediate-release medicines, manufacturer advises dose reduction to 1 mg twice daily if GFR less than or equal to 30 mL/minute. For modified-release capsules, manufacturer advises dose reduction to 2 mg once daily if GFR less than or equal to 30 mL/minute.
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There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution, powder Tablet CAUTIONARY AND ADVISORY LABELS 3 ▶Tolterodine tartrate (Non-proprietary) Tolterodine tartrate 1 mg Tolterodine 1mg tablets | 56 tablet P £29.03 DT = £1.70 Tolterodine tartrate 2 mg Tolterodine 2mg tablets | 56 tablet P £30.56 DT = £2.01 ▶Detrusitol (Upjohn UK Ltd) Genito-urinary system Tolterodine tartrate 1 mg Detrusitol 1mg tablets | 56 tablet P £29.03 DT = £1.70 Tolterodine tartrate 2 mg Detrusitol 2mg tablets | 56 tablet P £30.56 DT = £2.01 Modified-release capsule CAUTIONARY AND ADVISORY LABELS 3, 25 ▶Blerone XL (Zentiva) Tolterodine tartrate 4 mg Blerone XL 4mg capsules | 28 capsule P £12.80 DT = £25.78 ▶Detrusitol XL (Upjohn UK Ltd) Tolterodine tartrate 4 mg Detrusitol XL 4mg capsules | 28 capsule P £25.78 DT = £25.78 ▶Inconex XL (Sandoz Ltd) Tolterodine tartrate 4 mg Inconex XL 4mg capsules | 28 capsule P £21.91 DT = £25.78 ▶Mariosea XL (Teva UK Ltd) Tolterodine tartrate 2 mg Mariosea XL 2mg capsules | 28 capsule P £11.59 DT = £11.60 Tolterodine tartrate 4 mg Mariosea XL 4mg capsules | 28 capsule P £12.79 DT = £25.78 ▶Neditol XL (Aspire Pharma Ltd) Tolterodine tartrate 2 mg Neditol XL 2mg capsules | 28 capsule P £11.60 DT = £11.60 Tolterodine tartrate 4 mg Neditol XL 4mg capsules | 28 capsule P £12.89 DT = £25.78 ▶Preblacon XL (Accord Healthcare Ltd) Tolterodine tartrate 4 mg Preblacon XL 4mg capsules | 28 capsule P £25.78 DT = £25.78 ▶Santizor XL (Upjohn UK Ltd) Tolterodine tartrate 4 mg Santizor XL 4mg capsules | 28 capsule P £25.78 DT = £25.78 eiiii F 820
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2 mg twice daily, reduced if not tolerated to 1 mg
First-line fragment. Read the complete Indications and Dose section above.
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4 mg once daily
First-line fragment. Read the complete Indications and Dose section above.
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