Indications And Dose
Moderate to severe pain ▶BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION, OR BY SUBCUTANEOUS INJECTION ▶Adult: 50–100 mg every 4–6 hours, intravenous injection to be given over 2–3 minutes; Usual maximum 400 mg/24 hours Moderate to severe acute pain ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: Initially 100 mg, then 50–100 mg every 4–6 hours; Usual maximum 400 mg/24 hours ▶Adult: Initially 100 mg, then 50–100 mg every 4–6 hours; Usual maximum 400 mg/24 hours continued → Moderate to severe chronic pain ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 years: Initially 50 mg, then, adjusted according to response; Usual maximum 400 mg/24 hours ▶Adult: Initially 50 mg, then, adjusted according to response; Usual maximum 400 mg/24 hours Nervous system Postoperative pain ▶BY INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INFUSION, OR BY SUBCUTANEOUS INJECTION ▶Adult: Initially 100 mg, then 50 mg every 10–20 minutes if required up to total maximum 250 mg (including initial dose) in first hour, then 50–100 mg every 4–6 hours, intravenous injection to be given over 2–3 minutes; Usual maximum 400 mg/24 hours Moderate to severe pain (with modified-release 12-hourly preparations) ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Child 12–17 years: 50–100 mg twice daily, increased if necessary to 150–200 mg twice daily, doses exceeding the usual maximum not generally required; Usual maximum 400 mg/24 hours ▶Adult: 50–100 mg twice daily, increased if necessary to 150–200 mg twice daily, doses exceeding the usual maximum not generally required; Usual maximum 400 mg/24 hours Moderate to severe pain (with modified-release 24-hourly preparations) ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Child 12–17 years: Initially 100–150 mg once daily, increased if necessary up to 400 mg once daily; Usual maximum 400 mg/24 hours ▶Adult: Initially 100–150 mg once daily, increased if necessary up to 400 mg once daily; Usual maximum 400 mg/24 hours ZYDOL ® XL Moderate to severe pain ▶BY MOUTH USING MODIFIED-RELEASE TABLETS ▶Child 12–17 years: Initially 150 mg once daily, increased if necessary up to 400 mg once daily ▶Adult: Initially 150 mg once daily, increased if necessary up to 400 mg once daily
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