Drug reference
Moderate to severe pain ▶BY MOUTH ▶Child 12–17 years: 75/650 mg every 6 hours as required ▶Adult: 75/650 mg every 6 hours as required DOSE EQUIVALENCE AND CONVERSION ▶The proportions are expressed in the form x/y, where x and y are the strengths in milligrams of tramadol and paracetamol respectively.
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→Appendix 1: opioids. paracetamol
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There can be variation in the licensing of different medicines containing the same drug. Effervescent tablet CAUTIONARY AND ADVISORY LABELS 2, 13, 29, 30 ELECTROLYTES: May contain Sodium ▶Tramacet (Grunenthal Ltd) Tramadol hydrochloride 37.5 mg, Paracetamol 325 mg Tramacet 37.5mg/325mg effervescent tablets sugar-free | 60 tablet P £9.68 DT = £9.68 c Tablet CAUTIONARY AND ADVISORY LABELS 2, 25, 29, 30 ▶Tramadol with paracetamol (Non-proprietary) Tramadol hydrochloride 37.5 mg, Paracetamol 325 mg Tramadol 37.5mg / Paracetamol 325mg tablets | 60 tablet P £9.68 DT = £2.31 c Tramadol hydrochloride 75 mg, Paracetamol 650 mg Tramadol 75mg / Paracetamol 650mg tablets | 30 tablet P £19.50 c ▶Tramacet (Grunenthal Ltd) Tramadol hydrochloride 37.5 mg, Paracetamol 325 mg Tramacet 37.5mg/325mg tablets | 60 tablet P £9.68 DT = £2.31 c ▶Trapadex (Noumed Life Sciences Ltd) Tramadol hydrochloride 37.5 mg, Paracetamol 325 mg Trapadex 37.5mg/325mg tablets | 60 tablet P s DT = £2.31 c 6.1 Headache Cluster headache and other trigeminal autonomic cephalalgias Management Cluster headache rarely responds to standard analgesics. Sumatriptan p. 503 given by subcutaneous injection is the drug of choice for the treatment of cluster headache. If an injection is unsuitable, sumatriptan nasal spray or zolmitriptan nasal spray p. 504 [both unlicensed use] may be used. Alternatively, 100% oxygen at a rate of 10–15 litres/minute for 10–20 minutes is useful in aborting an attack. Prophylaxis of cluster headache is considered if the attacks are frequent, last over 3 weeks, or if they cannot be treated effectively. Verapamil hydrochloride p. 175 or lithium [both unlicensed use] are used for prophylaxis. Prednisolone p. 716 can be used for short-term prophylaxis of episodic cluster headache [unlicensed use] either as monotherapy, or in combination with verapamil hydrochloride during verapamil titration. Ergotamine tartrate p. 500, used on an intermittent basis is an alternative for patients with short bouts, but it should not be used for prolonged periods. The other trigeminal autonomic cephalalgias, paroxysmal hemicrania (sensitive to indometacin p. 1206), and short- lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, are seen rarely and are best managed by a specialist. Other drugs used for Headache Clonidine hydrochloride, p. 156 ANTIHISTAMINES › SEDATING ANTIHISTAMINES
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75/650 mg every 6 hours as required
First-line fragment. Read the complete Indications and Dose section above.
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