Names and pronunciation
(tran-doe′la-prill) Marik
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Drug reference
(tran-doe′la-prill) Marik
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Func. class.: Antihypertensive
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Chem. class.: Angiotension- converting enzyme inhibitor
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USES: Hypertension, heart failure, left ventricular dysfunction post MI
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CONTRAINDICATIONS: Breast- feeding, hypersensitivity, history of angioedema
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Black Box Warning: Pregnancy
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DOSAGE AND ROUTES Hypertension • Adult: PO 1 mg/day; 2 mg/day in Afri- can Americans; make dosage adjustment ≥1 wk; max 8 mg/day Heart failure, left ventricular dysfunction post MI • Adult: PO 1 mg/day, titrate upward to 4 mg/day if tolerated, continue for 2-4 yr Renal/hepatic dose • Adult: PO CCr <30 mL/min or hepatic disease, 0.5 mg/day
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Available forms: Tabs 1, 2 ,4 mg
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• Adult: PO 1 mg/day; 2 mg/day in Afri- can Americans; make dosage adjustment ≥1 wk; max 8 mg/day Heart failure, left ventricular dysfunction post MI
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• Adult: PO 1 mg/day, titrate upward to 4 mg/day if tolerated, continue for 2-4 yr Renal/hepatic dose
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• Adult: PO CCr <30 mL/min or hepatic disease, 0.5 mg/day
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