Names and pronunciation
(tras-tooz′ue-mab/hye-al-ur-on′i- dase) Herceptin Hylecta
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Drug reference
(tras-tooz′ue-mab/hye-al-ur-on′i- dase) Herceptin Hylecta
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Func. class.: Antineoplastic, endogly- cosidases
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USES: Adjuvant treatment of HER2- overexpressing node positive/node negative (ER/PR negative or with one high-risk feature) in breast cancer, as part of a regimen with doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel; as part of a regimen with docetaxel and carboplatin; as a single agent anthracycline-based therapy; HER2-overexpressing metastatic breast cancer (in combination with paclitaxel); single-agent treatment of HER2- overexpressing breast cancer
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CONTRAINDICATIONS Hypersensitivity
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Black Box Warning: Pregnancy, CV tox- icity, pulmonary toxicity
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DOSAGE AND ROUTES Breast cancer, adjuvant treatment, HER2+ • Adult: SUBCUT: Trastuzumab 600 mg/hyaluronidase 10,000 units once q3wk × 52 wk or until disease pro- gression or unacceptable toxicity; give with doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel; or in combination with docetaxel and car- boplatin; or as a single agent following multimodality anthracycline-based therapy Breast cancer, metastatic, HER2+ • Adult: SUBCUT: Trastuzumab 600 mg/ hyaluronidase 10,000 units once q3wk (with paclitaxel or as a single agent fol- lowing one or more chemotherapy regi- mens for metastatic disease) until dis- ease progression or unacceptable toxicity
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Available forms: Injection 600 mg/ 10,000 units/5 mL in single-dose vial See Appendix B
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• Adult: SUBCUT: Trastuzumab 600 mg/hyaluronidase 10,000 units once q3wk × 52 wk or until disease pro- gression or unacceptable toxicity; give with doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel; or in combination with docetaxel and car- boplatin; or as a single agent following multimodality anthracycline-based therapy Breast cancer, metastatic, HER2+
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• Adult: SUBCUT: Trastuzumab 600 mg/ hyaluronidase 10,000 units once q3wk (with paclitaxel or as a single agent fol- lowing one or more chemotherapy regi- mens for metastatic disease) until dis- ease progression or unacceptable toxicity
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