Drug reference

Treosulfan

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 972

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Ovarian cancer ▶BY MOUTH, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION, OR BY INTRAPERITONEAL INSTILLATION ▶Adult: (consult product literature)

PDF page 972

Cautions

Avoid in Acute porphyrias p. 1120

PDF page 972

Safety

Important Safety Information

RISKS OF INCORRECT DOSING OF ORAL ANTI-CANCER MEDICINES See Cytotoxic drugs p. 938.

PDF page 972

Interactions

→Appendix 1: alkylating agents

PDF page 972

Side Effects

GENERAL SIDE-EFFECTS ▶Common or very common Alopecia. anaemia. bone marrow disorders. increased risk of infection. leucopenia. nausea. skin reactions. thrombocytopenia. vomiting ▶Uncommon Neoplasms. treatment related secondary malignancy ▶Rare or very rare Addison’s disease. cardiomyopathy. cystitis haemorrhagic. hypoglycaemia. inﬂuenza like illness. paraesthesia. respiratory disorders. scleroderma. sepsis SPECIFIC SIDE-EFFECTS ▶Uncommon ▶With oral use Stomatitis ▶Rare or very rare ▶With intravenous use Inﬂammation localised SIDE-EFFECTS, FURTHER INFORMATION Prolonged use of treosulfan is associated with an increased incidence of acute non-lymphocytic leukaemia.

PDF page 972

Conception And Contraception

Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 972

Pregnancy

Avoid. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 972

Breast Feeding

Discontinue breast-feeding.

PDF page 972

Dose and formulations

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Capsule CAUTIONARY AND ADVISORY LABELS 25 ▶Treosulfan (Non-proprietary) Treosulfan 250 mg Treosulfan 250mg capsules | 100 capsule P £653.20 Powder for solution for injection ▶Treosulfan (Non-proprietary) Treosulfan 1 gram Treosulfan 1g powder for solution for injection vials | 5 vial P £494.40 Trecondi 1g powder for solution for infusion | 5 vial P £494.40 Treosulfan 5 gram Treosulfan 5g powder for solution for injection vials | 5 vial P £2,434.25 Trecondi 5g powder for solution for infusion | 5 vial P £2,434.25 ANTINEOPLASTIC DRUGS › ANTHRACYCLINES AND RELATED DRUGS

PDF page 972

Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 972

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Treosulfan

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 972

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

Ovarian cancer ▶BY MOUTH, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION, OR BY INTRAPERITONEAL INSTILLATION ▶Adult: (consult product literature)

PDF page 972

Cautions

Avoid in Acute porphyrias p. 1120

PDF page 972

Safety

Important Safety Information

RISKS OF INCORRECT DOSING OF ORAL ANTI-CANCER MEDICINES See Cytotoxic drugs p. 938.

PDF page 972

Interactions

→Appendix 1: alkylating agents

PDF page 972

Side Effects

PDF page 972

Conception And Contraception

Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 972

Pregnancy

Avoid. See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.

PDF page 972

Breast Feeding

Discontinue breast-feeding.

PDF page 972

Dose and formulations

Medicinal Forms

PDF page 972

Dose text by age group

Adult

(consult product literature)

First-line fragment. Read the complete Indications and Dose section above.

PDF page 972

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.