Drug Action
Typhoid vaccine protects against typhoid fever caused by Salmonella typhi infection; it is available as an oral live attenuated vaccine and an injectable polysaccharide vaccine.
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Drug reference
Typhoid vaccine protects against typhoid fever caused by Salmonella typhi infection; it is available as an oral live attenuated vaccine and an injectable polysaccharide vaccine.
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Immunisation against typhoid fever [in children at high risk of typhoid fever] ▶BY INTRAMUSCULAR INJECTION ▶Child 12–23 months: 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection, response may be suboptimal Immunisation against typhoid fever ▶BY INTRAMUSCULAR INJECTION ▶Child 2–17 years: 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection ▶Adult: 0.5 mL for 1 dose, dose should be given at least 2 weeks before potential exposure to typhoid infection ▶BY MOUTH ▶Child 5–17 years: 1 capsule every 2 days for 3 doses (on days 1, 3, and 5), course should be completed at least 1 week before potential exposure to typhoid infection ▶Adult: 1 capsule every 2 days for 3 doses (on days 1, 3, and 5), course should be completed at least 1 week before potential exposure to typhoid infection Booster ▶BY INTRAMUSCULAR INJECTION ▶Child 2–17 years: 0.5 mL for 1 dose every 3 years ▶Adult: 0.5 mL for 1 dose every 3 years ▶BY MOUTH ▶Child 5–17 years: 1 capsule every 2 days for 3 doses (on days 1, 3, and 5) every 3 years ▶Adult: 1 capsule every 2 days for 3 doses (on days 1, 3, and 5) every 3 years l UNLICENSED USE ▶With intramuscular use in children Not licensed for use in children under 2 years.
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▶With oral use Acute gastro-intestinal illness
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→Appendix 1: live vaccines
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GENERAL SIDE-EFFECTS Shock SPECIFIC SIDE-EFFECTS ▶Common or very common ▶With oral use Gastrointestinal discomfort ▶Frequency not known ▶With oral use Asthenia. back pain. chills. flatulence. influenza like illness. paraesthesia ▶With parenteral use Abdominal pain. asthma. syncope
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Capsule should be taken one hour before a meal. Swallow as soon as possible after placing in mouth with a cold or lukewarm drink. l HANDLING AND STORAGE ▶With oral use It is important to store capsules in a refrigerator.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Typhim Vi (Sanofi Pasteur) Salmonella typhi Vi capsular polysaccharide 50 microgram per 1 ml Typhim Vi 25micrograms/0.5ml vaccine solution for injection pre-filled syringes | 1 pre-filled disposable injection P £11.16 DT = £11.16 | 10 pre-filled disposable injection P £111.60 DT = £111.60 Gastro-resistant capsule CAUTIONARY AND ADVISORY LABELS 25 ▶Vivotif (Emergent BioSolutions UK) Vivotif vaccine gastro-resistant capsules | 3 capsule P £14.77 DT = £14.77 Combinations available: Hepatitis A with typhoid vaccine, p. 1389 VACCINES › VIRAL VACCINES
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▶With oral use Patients or carers should be given advice on how to administer and store typhoid vaccine capsules.
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0.5 mL for 1 dose, dose should be given at least
First-line fragment. Read the complete Indications and Dose section above.
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1 capsule every 2 days for 3 doses (on days 1, 3,
First-line fragment. Read the complete Indications and Dose section above.
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0.5 mL for 1 dose every 3 years
First-line fragment. Read the complete Indications and Dose section above.
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1 capsule every 2 days for 3 doses (on days 1, 3,
First-line fragment. Read the complete Indications and Dose section above.
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