Drug reference

vandetanib

Mosby’s 2024 Nursing Drug Reference

Source: Mosby’s 2024 Nursing Drug Reference
PDF pages: 1353

Overview

Names and pronunciation

(van-det′a-nib) Caprelsa

PDF page 1353

Functional class

Func. class.: Antineoplastic-tyrosine kinase inhibitor

PDF page 1353

Uses

USES: Treatment of metastatic/unre sectable locally-advanced medullary thyroid cancer

PDF page 1353

Safety

Warnings and precautions

Black Box Warning: QTc prolongation

PDF page 1353

Dose and formulations

Dosage and routes

DOSAGE AND ROUTES • Adult: PO 300 mg daily, do not initiate treatment unless QTcF ≤450 msec

PDF page 1353

Available forms

Available forms: Tabs 100, 300 mg Renal dose Adult: PO CCr ≥50 mL/min: No change; CCr 30-49 mL/min: Reduce starting dose to 200 mg and monitor QT interval; CCr <30 mL/min: Do not use

PDF page 1353

Dose text by age group

Adult

• Adult: PO 300 mg daily, do not initiate treatment unless QTcF ≤450 msec

PDF page 1353

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

vandetanib

Mosby’s 2024 Nursing Drug Reference

Source: Mosby’s 2024 Nursing Drug Reference
PDF pages: 1353

Overview

Names and pronunciation

(van-det′a-nib) Caprelsa

PDF page 1353

Functional class

Func. class.: Antineoplastic-tyrosine kinase inhibitor

PDF page 1353

Uses

USES: Treatment of metastatic/unre sectable locally-advanced medullary thyroid cancer

PDF page 1353

Safety

Warnings and precautions

Black Box Warning: QTc prolongation

PDF page 1353

Dose and formulations

Dosage and routes

DOSAGE AND ROUTES • Adult: PO 300 mg daily, do not initiate treatment unless QTcF ≤450 msec

PDF page 1353

Available forms

Available forms: Tabs 100, 300 mg Renal dose Adult: PO CCr ≥50 mL/min: No change; CCr 30-49 mL/min: Reduce starting dose to 200 mg and monitor QT interval; CCr <30 mL/min: Do not use

PDF page 1353

Dose text by age group

Adult

• Adult: PO 300 mg daily, do not initiate treatment unless QTcF ≤450 msec

PDF page 1353

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.