Indications And Dose
Variety of cancers including leukaemias, lymphomas, and some solid tumours (e.g. breast and lung cancer) ▶Adult: (consult product literature)
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Drug reference
Variety of cancers including leukaemias, lymphomas, and some solid tumours (e.g. breast and lung cancer) ▶Adult: (consult product literature)
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Intrathecal injection contra- indicated.
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Caution in handling—irritant to tissues
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Vinblastine is for intravenous administration only. Inadvertent intrathecal administration can cause severe neurotoxicity, which is usually fatal. The National Patient Safety Agency has advised (August 2008) that adult and teenage patients treated in an adult or adolescent unit should receive their vinca alkaloid dose in a 50 mL minibag. Teenagers and children treated in a child unit may receive their vinca alkaloid dose in a syringe.
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→Appendix 1: vinca alkaloids
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▶Rare or very rare Hearing impairment. nerve disorders. vestibular damage ▶Frequency not known Abdominal pain. acute respiratory distress syndrome (ARDS). alopecia (reversible). anaemia. appetite decreased. asthenia. balance impaired. cancer pain. constipation. depression. diarrhoea. dizziness. dyspnoea. haemorrhage. headache. hypertension. ileus. increased risk of infection. leucopenia (dose-limiting). malaise. mediastinal disorder. myalgia. myocardial infarction. nausea. nystagmus. oral blistering. pain. Raynaud’s phenomenon. reflexes absent. seizure. sensation abnormal. SIADH. skin reactions. stroke. thrombocytopenia. vertigo. vomiting
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Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Avoid (limited experience suggests fetal harm; teratogenic in animal studies). See also Pregnancy Immune system and malignant disease and reproductive function in Cytotoxic drugs p. 938.
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Discontinue breast-feeding.
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Manufacturer advises caution in significantly impaired hepatic or biliary function. Dose adjustments Manufacturer advises consider initial dose reduction in significantly impaired hepatic or biliary function.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Vinblastine sulfate (Non-proprietary) Vinblastine sulfate 1 mg per 1 ml Vinblastine 10mg/10ml solution for injection vials | 5 vial P £85.00 (Hospital only)
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(consult product literature)
First-line fragment. Read the complete Indications and Dose section above.
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