→Appendix 1: vitamin A
PDF page 1162
Overdose Massive overdose can cause rough skin, dry hair,
an enlarged liver, and increases in erythrocyte
sedimentation rate, serum calcium and serum alkaline
phosphatase concentration.
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Excessive doses may be teratogenic. In view
of evidence suggesting that high levels of vitamin A may
cause birth defects, women who are (or may become)
pregnant are advised not to take vitamin A supplements
(including tablets and fish liver oil drops), except on the
advice of a doctor or an antenatal clinic; nor should they
eat liver or products such as liver paté or liver sausage.
PDF pages 1162, 1163
Theoretical risk of toxicity in infants of
mothers taking large doses.
PDF page 1163
Treatment is sometimes
initiated with very high doses of vitamin A and the child
should be monitored closely; very high doses are
associated with acute toxicity.
PDF page 1163