Indications And Dose
Severe depletion or malabsorption of vitamins B and C postoperatively ▶BY INTRAVENOUS INFUSION, OR BY DEEP INTRAMUSCULAR INJECTION ▶Adult: (consult product literature) Treatment of suspected or established Wernicke’s encephalopathy ▶BY INTRAVENOUS INFUSION ▶Adult: 2–3 pairs 3 times a day for 3–5 days, followed by 1 pair once daily for a further 3–5 days or for as long as improvement continues Prophylaxis of Wernicke’s encephalopathy [assisted alcohol withdrawal in an inpatient setting] ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: 1 pair once daily for at least 5 days and up to 7 days if required, give into the gluteal muscle Severe depletion or malabsorption of vitamins B and C in psychosis following narcosis or electroconvulsive therapy | Severe depletion or malabsorption of vitamins B and C following toxicity from acute infections ▶BY INTRAVENOUS INFUSION, OR BY DEEP INTRAMUSCULAR INJECTION ▶Adult: 1 pair twice daily for up to 7 days, give deep intramuscular injection into the gluteal muscle Severe depletion or malabsorption of vitamins B and C in haemodialysis ▶BY INTRAVENOUS INFUSION ▶Adult: 1 pair every 2 weeks DOSE EQUIVALENCE AND CONVERSION ▶Dose is expressed in pairs of ampoules. ▶For intravenous administration, 1 pair is one 5 mL ampoule containing thiamine 250 mg, riboflavin 4 mg and pyridoxine 50 mg, and one 5 mL ampoule containing ascorbic acid 500 mg, nicotinamide 160 mg and glucose 1000 mg. ▶For intramuscular administration, 1 pair is one 5 mL ampoule containing thiamine 250 mg, riboflavin 4 mg and pyridoxine 50 mg, and one 2 mL ampoule containing ascorbic acid 500 mg and nicotinamide 160 mg. l UNLICENSED USE Vitamin B substances with ascorbic acid may be used as detailed below, although these situations are considered outside the scope of its licence: . g durations and further dosing for treatment of suspected or established Wernicke’s encephalopathy . prophylaxis of Wernicke’s encephalopathy k
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