Drug reference

Zidovudine with lamivudine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 715

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

HIV infection in combination with other antiretroviral drugs ▶BY MOUTH ▶Adult: 1 tablet twice daily

PDF page 715

Contra Indications

Acute porphyrias p. 1120

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Cautions

Haemophilia (increased risk of bleeding)

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Safety

Interactions

→Appendix 1: lamivudine. zidovudine

PDF page 715

Renal Impairment

Avoid if eGFR less than 50 mL/minute/1.73 m2 (consult product literature).

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Side Effects

▶Common or very common Alopecia. anaemia. angioedema . anxiety. appetite abnormal. arthralgia. asthenia. diabetes mellitus. diarrhoea. dizziness. dry mouth. dyslipidaemia. dyspnoea. fever. gastrointestinal discomfort. gastrointestinal disorders. headache. hepatic disorders. hypersensitivity. hypertension. malaise. muscle complaints. nausea. neutropenia. oral ulceration. pancreatitis. peripheral neuropathy. seizure. skin reactions. sleep disorders. taste altered. vomiting ▶Uncommon Drowsiness. immune reconstitution inﬂammatory syndrome. osteonecrosis. Stevens-Johnson syndrome. weight increased

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Hepatic Impairment

In general, manufacturers advise use with caution in patients with chronic hepatitis B or C (increased risk of hepatic side-effects). eiiii F above

PDF page 715

Dose and formulations

Directions For Administration

COMBIVIR ® TABLETS Tablets may be crushed and mixed with semi-solid food or liquid just before administration.

PDF page 715

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Tablet ▶Zidovudine with lamivudine (Non-proprietary) Lamivudine 150 mg, Zidovudine 300 mg Zidovudine 300mg / Lamivudine 150mg tablets | 60 tablet P £240.10–£255.10 DT = £300.12 ▶Combivir (ViiV Healthcare UK Ltd) Lamivudine 150 mg, Zidovudine 300 mg Combivir 150mg/300mg tablets | 60 tablet P £300.12 DT = £300.12 ANTIVIRALS › PROTEASE INHIBITORS, HIV Protease inhibitors f

PDF page 715

Dose text by age group

Adult

1 tablet twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 715

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

Zidovudine with lamivudine

BNF 80 (2020–2021)

Source: BNF 80 (2020–2021)
PDF pages: 715

Review source pages for extracted sections and age labels. BNF dose snippets show only their first line.

Overview

Indications And Dose

HIV infection in combination with other antiretroviral drugs ▶BY MOUTH ▶Adult: 1 tablet twice daily

PDF page 715

Contra Indications

Acute porphyrias p. 1120

PDF page 715

Cautions

Haemophilia (increased risk of bleeding)

PDF page 715

Safety

Interactions

→Appendix 1: lamivudine. zidovudine

PDF page 715

Renal Impairment

Avoid if eGFR less than 50 mL/minute/1.73 m2 (consult product literature).

PDF page 715

Side Effects

PDF page 715

Hepatic Impairment

In general, manufacturers advise use with caution in patients with chronic hepatitis B or C (increased risk of hepatic side-effects). eiiii F above

PDF page 715

Dose and formulations

Directions For Administration

COMBIVIR ® TABLETS Tablets may be crushed and mixed with semi-solid food or liquid just before administration.

PDF page 715

Medicinal Forms

PDF page 715

Dose text by age group

Adult

1 tablet twice daily

First-line fragment. Read the complete Indications and Dose section above.

PDF page 715

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.