Drug reference

ziv-aflibercept

Mosby’s 2024 Nursing Drug Reference

Source: Mosby’s 2024 Nursing Drug Reference
PDF pages: 1399

Review source pages for extracted sections and age labels.

Overview

Names and pronunciation

(ziv-a-flih′ber-sept) Zaltrap

PDF page 1399

Functional class

Func. class.: Antineoplastic

PDF page 1399

Chemical class

Chem. class.: Signal transduction inhibitor (STI), fusion protein

PDF page 1399

Uses

USES: Metastatic colorectal cancer that is resistant or has progressed after an oxaliplatin-containing regimen in combination with 5-fluorouracil, leucov orin, irinotecan (FOLFIRI)

PDF page 1399

Dose and formulations

Dosage and routes

DOSAGE AND ROUTES • Adult: IV 4 mg/kg over 1 hr on day 1 q2wk with the FOLFIRI regimen • Do not use in severe hypertension until controlled, then use lower dose

PDF page 1399

Available forms

Available forms: Solution for injection 100 mg/4 mL; 200 mg/8 mL

PDF page 1399

Dose text by age group

Adult

• Adult: IV 4 mg/kg over 1 hr on day 1 q2wk with the FOLFIRI regimen

PDF page 1399

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.

Drug reference

ziv-aflibercept

Mosby’s 2024 Nursing Drug Reference

Source: Mosby’s 2024 Nursing Drug Reference
PDF pages: 1399

Review source pages for extracted sections and age labels.

Overview

Names and pronunciation

(ziv-a-flih′ber-sept) Zaltrap

PDF page 1399

Functional class

Func. class.: Antineoplastic

PDF page 1399

Chemical class

Chem. class.: Signal transduction inhibitor (STI), fusion protein

PDF page 1399

Uses

USES: Metastatic colorectal cancer that is resistant or has progressed after an oxaliplatin-containing regimen in combination with 5-fluorouracil, leucov orin, irinotecan (FOLFIRI)

PDF page 1399

Dose and formulations

Dosage and routes

DOSAGE AND ROUTES • Adult: IV 4 mg/kg over 1 hr on day 1 q2wk with the FOLFIRI regimen • Do not use in severe hypertension until controlled, then use lower dose

PDF page 1399

Available forms

Available forms: Solution for injection 100 mg/4 mL; 200 mg/8 mL

PDF page 1399

Dose text by age group

Adult

• Adult: IV 4 mg/kg over 1 hr on day 1 q2wk with the FOLFIRI regimen

PDF page 1399

Age labels are extracted for navigation. Check the complete source section and current local guidance before clinical use.