Names and pronunciation
(zoh′leh-drah′nick ass′id) Aclasta , Reclast, Zometa
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Drug reference
(zoh′leh-drah′nick ass′id) Aclasta , Reclast, Zometa
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Func. class.: Bone-resorption inhibitor
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Chem. class.: Bisphosphonate
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USES: Moderate to severe hyper calcemia associated with malignancy; multiple myeloma; bone metastases from solid tumors (used with antineoplastics); active Paget’s disease; osteoporosis, glucocorticoid-induced osteoporosis, osteoporosis prophylaxis in postmen opausal women
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DOSAGE AND ROUTES Hypercalcemia of malignancy • Adult: IV INFUSION 4 mg, given as single infusion over ≥15 min; may re-treat with 4 mg if serum calcium does not return to normal within 1 wk Multiple myeloma/metastatic bone lesions • Adult: IV INFUSION 4 mg, give over 15 min q3-4wk Osteoporosis • Adult: IV INFUSION 5 mg over ≥15 min q12mo Active Paget’s disease (Reclast) • Adult: IV INFUSION 5 mg over ≥15 min with 1500 mg elemental calcium in divided doses and 800 IU of vitamin D Osteoporosis prophylaxis (Reclast), postmenopausal women • Adult: IV INFUSION 5 mg every other year Osteoporosis prophylaxis (Reclast) when taking systemic glucocorticoids • Adult: IV 5 mg every year Renal dose • Adult: IV INFUSION CCr 50-60 mL/min, 3.5 mg; CCr 40-49 mL/min, 3.3 mg; CCr 30- 39 mL/min, 3 mg; CCr <30 mL/min, do not use Osteopenia prevention in androgen deprivation treatment (prostate cancer) (unlabeled) • Adult: IV 4 mg q6-12mo or 5 mg q12mo
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Available forms: sol for inj 4 mg/5 mL; (Aclasta , Reclast) inj 5 mg/100 mL
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• Adult: IV INFUSION 4 mg, given as single infusion over ≥15 min; may re-treat with 4 mg if serum calcium does not return to normal within 1 wk Multiple myeloma/metastatic bone lesions
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• Adult: IV INFUSION 4 mg, give over 15 min q3-4wk Osteoporosis
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• Adult: IV INFUSION 5 mg over ≥15 min q12mo Active Paget’s disease (Reclast)
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• Adult: IV INFUSION 5 mg over ≥15 min with 1500 mg elemental calcium in divided doses and 800 IU of vitamin D Osteoporosis prophylaxis (Reclast), postmenopausal women
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• Adult: IV INFUSION 5 mg every other year Osteoporosis prophylaxis (Reclast) when taking systemic glucocorticoids
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• Adult: IV 5 mg every year Renal dose
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• Adult: IV INFUSION CCr 50-60 mL/min, 3.5 mg; CCr 40-49 mL/min, 3.3 mg; CCr 30- 39 mL/min, 3 mg; CCr <30 mL/min, do not use Osteopenia prevention in androgen deprivation treatment (prostate cancer) (unlabeled)
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• Adult: IV 4 mg q6-12mo or 5 mg q12mo
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