Drug reference
Maintenance in schizophrenia and paranoid psychoses ▶BY DEEP INTRAMUSCULAR INJECTION ▶Adult: Test dose 100 mg, dose to be administered into Nervous system the upper outer buttock or lateral thigh, followed by 200–500 mg after at least 7 days, then 200–500 mg every 1–4 weeks, adjusted according to response, higher doses of more than 500mg can be used; do not exceed 600 mg weekly ▶Elderly: A quarter to half usual starting dose to be used
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CNS depression. comatose states. phaeochromocytoma
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Hyperthyroidism. hypothyroidism. QT interval prolongation. when transferring from oral to depot therapy, the dose by mouth should be reduced gradually
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When prescribing, dispensing, or administering, check that this is the correct preparation—this preparation is used for maintenance treatment and should not be used for the short-term management of an acute episode. SAFE PRACTICE Zuclopenthixol decanoate has been confused with zuclopenthixol acetate; care must be taken to ensure the correct drug is prescribed and dispensed.
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→Appendix 1: zuclopenthixol
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Anxiety. appetite abnormal. asthenia. concentration impaired. confusion. depression. diarrhoea . dyspnoea. eye disorders. fever. flatulence. gait abnormal . gastrointestinal discomfort. glucose tolerance impaired. headaches. hepatic disorders. hot flush. hyperacusia. hyperglycaemia. hyperhidrosis. hyperlipidaemia. hypersalivation. hypothermia. malaise. memory loss. muscle complaints. nasal congestion. nausea. neuromuscular dysfunction. pain. palpitations. paraesthesia. photosensitivity reaction. reflexes increased . seborrhoea. sexual dysfunction. skin reactions. sleep disorders. speech disorder. syncope. thirst. thrombocytopenia. tinnitus. urinary disorders. vertigo. vision disorders. vulvovaginal dryness. weight decreased. withdrawal syndrome SIDE-EFFECTS, FURTHER INFORMATION Side-effects may persist until the drug has been cleared from its depot site.
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Manufacturer advises caution— monitor serum drug concentration. Dose adjustments Manufacturer advises dose reduction to half the recommended dose.
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Dose adjustments Start with small doses in severe renal impairment because of increased cerebral sensitivity.
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Treatment requires careful monitoring for optimum effect.
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In general not more than 2–3 mL of oily injection should be administered at any one site. Correct injection technique (including use of z-track technique) and rotation of injection sites are essential. When initiating therapy with sustained-release preparations of conventional antipsychotics, patients should first be given a small test-dose as undesirable side- effects are prolonged.
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There can be variation in the licensing of different medicines containing the same drug. Solution for injection ▶Clopixol (Lundbeck Ltd) Zuclopenthixol decanoate 200 mg per 1 ml Clopixol 200mg/1ml solution for injection ampoules | 10 ampoule P £31.51 DT = £31.51 Zuclopenthixol decanoate 500 mg per 1 ml Clopixol Conc 500mg/1ml solution for injection ampoules | 5 ampoule P £37.18 DT = £37.18 ANTIPSYCHOTICS › SECOND-GENERATION eiiii F 401
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Test dose 100 mg, dose to be administered into
First-line fragment. Read the complete Indications and Dose section above.
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A quarter to half usual starting dose to be used
First-line fragment. Read the complete Indications and Dose section above.
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