Therapeutic Action
Antiretroviral, inhibitor of HIV integrase
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Individual generic drug information
Extracted information for DOLUTEGRAVIR only.
Antiretroviral, inhibitor of HIV integrase
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HIV infection, in combination with other antiretrovirals
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Extracted information for DOLUTEGRAVIR only.
Administer with caution to patients with severe hepatic impairment or coinfection with hepatitis B or hepatitis C virus. May cause: insomnia, depression, anxiety, dizziness, headache, skin rash, gastrointestinal disturbances (nausea, vomiting, diarrhoea, etc.); rarely: hepatotoxicity, hypersensitivity reactions. Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.), ferrous salts, calcium and zinc salts (effect of dolutegravir decreased). Take these drugs at least 6 hours before or 2 hours after dolutegravir. In patients taking: metformin: monitor closely blood glucose level and renal function and adjust dose as needed (effect of metformin increased). Do not exceed 1 g of metformin daily. enzyme-inducing drug (e.g. rifampicin, carbamazepine, phenytoin, phenobarbital, efavirenz, nevirapine): double the daily dose of dolutegravir (effect of dolutegravir decreased), e.g. 30 mg 2 times daily rather than 30 mg once daily, and maintain the double dose for 2 weeks after enzyme-inducing drug treatment completion. In adolescents and women of childbearing age, offer hormonal contraception or an intrauterine device. Pregnancy: small increased risk of neural tube defects but the benefits outweigh the risks. The administration of folic acid during the first trimester may reduce this risk.
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Extracted information for DOLUTEGRAVIR only.
10 mg dispersible tablet 50 mg tablet
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The daily dose is administered once daily. Child 1 month and over and adult: Weight Daily dose Tablets 3 to < 6 kg 5 mg ½ disp tab 10 mg 6 to < 10 kg 15 mg 1 ½ disp tab 10 mg 10 to < 14 kg 20 mg 2 disp tab 10 mg 14 to < 20 kg 25 mg 2 ½ disp tab 10 mg 30 mg 3 disp tab 10 mg ≥ 20 kg or 50 mg or 1 tab 50 mg
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Depending on the efficacy and tolerance of dolutegravir.
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Extracted information for DOLUTEGRAVIR only.
Three 10 mg dispersible tablets are equivalent to one 50 mg tablet. In children 20 kg and over, preferably use 50 mg tablet unless they cannot swallow tablets. Do not cut, crush or chew dispersible tablets. They can be swallowed or dispersed in a small amount of water. Dolutegravir is also used for HIV post-exposure prophylaxis in combination with other antiretrovirals. Also comes in fixed-dose combinations: 300 mg tenofovir /300 mg lamivudine /50 mg dolutegravir. Preferably use this formulation when available in adolescents 30 kg and over and adults. In patients taking enzyme-inducing drugs, administer the fixed-dose combination in the morning and dolutegravir 50 mg in the evening. 60 mg abacavir/30 mg lamivudine/5 mg dolutegravir dispersible tablet. Preferably use this formulation when available in children 3 months of age and over and weighing from 6 to under 25 kg.
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– – Below 25 °C
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Filter the extracted dose blocks for this individual drug.