Individual generic drug information

acetazolamide

Reference monograph

Part of registered formulation

ACETAZOLAMIDE

Reference record: Acetazolamide
Source: BNF 80 (2020–2021)
Printed source pages: 1266, 1267
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Acetazolamide only.

Indications And Dose

Reduction of intra-ocular pressure in open-angle glaucoma | Reduction of intra-ocular pressure in secondary glaucoma | Reduction of intra-ocular pressure perioperatively in angle-closure glaucoma ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES, OR BY INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION ▶Adult: 0.25–1 g daily in divided doses, intramuscular injection preferably avoided because of alkalinity Glaucoma ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Adult: 250–500 mg daily Epilepsy ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES, OR BY INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION ▶Adult: 0.25–1 g daily in divided doses, intramuscular injection preferably avoided because of alkalinity

Source pages 1266, 1267

Contra Indications

Adrenocortical insufﬁciency. hyperchloraemic acidosis. hypokalaemia. hyponatraemia. long-term administration in chronic angle-closure glaucoma

Source page 1267

Cautions

Avoid extravasation at injection site (risk of necrosis). diabetes mellitus. elderly. impaired alveolar ventilation (risk of acidosis). long-term use. pulmonary obstruction (risk of acidosis). renal calculi

Source page 1267

Allergy And Cross Sensitivity

Contra-indicated if history of sulfonamide hypersensitivity.

Source page 1267

Safety

Extracted information for Acetazolamide only.

Interactions

→Appendix 1: acetazolamide

Source page 1267

Side Effects

GENERAL SIDE-EFFECTS ▶Common or very common Haemorrhage. metabolic acidosis . nephrolithiasis. sensation abnormal ▶Uncommon Bone marrow disorders. depression. dizziness . electrolyte imbalance. hearing impairment. hepatic disorders. leucopenia. nausea. renal colic. renal impairment. renal lesions. severe cutaneous adverse reactions (SCARs). skin reactions. thrombocytopenia. tinnitus. urinary tract discomfort. urine abnormalities. vomiting ▶Rare or very rare Anaphylactic reaction. appetite disorder . confusion. diarrhoea. fatigue. fever. ﬂushing. headache . irritability. libido decreased. paralysis. photosensitivity reaction. seizure ▶Frequency not known Agranulocytosis. drowsiness. myopia. polyuria. taste altered. thirst SPECIFIC SIDE-EFFECTS ▶Uncommon ▶With oral use Osteomalacia ▶Rare or very rare ▶With oral use Ataxia. hyperglycaemia. hypoglycaemia. renal tubular necrosis ▶Frequency not known ▶With oral use Agitation SIDE-EFFECTS, FURTHER INFORMATION Acetazolamide is a sulfonamide derivative; blood disorders, rashes, and other sulfonamide-related side-effects occur occasionally — patients should be told to report any unusual skin rash. If electrolyte disturbances and metabolic acidosis occur, these can be corrected by administering bicarbonate.

Source page 1267

Pregnancy

Manufacturer advises avoid, especially in ﬁrst trimester (toxicity in animal studies).

Source page 1267

Breast Feeding

Amount too small to be harmful.

Source page 1267

Hepatic Impairment

Manufacturer advises avoid.

Source page 1267

Renal Impairment

Avoid—risk of metabolic acidosis.

Source page 1267

Monitoring Requirements

Monitor blood count and plasma electrolyte concentrations with prolonged use.

Source page 1267

Dose and formulations

Extracted information for Acetazolamide only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet CAUTIONARY AND ADVISORY LABELS 3 ▶Acetazolamide (Non-proprietary) Acetazolamide 250 mg Acetazolamide 250mg tablets | 112 tablet P £75.36 DT = £8.36 Powder for solution for injection ▶Diamox (Advanz Pharma) Acetazolamide 500 mg Diamox Sodium Parenteral 500mg powder for solution for injection vials | 1 vial P £14.76 Modified-release capsule CAUTIONARY AND ADVISORY LABELS 3, 25 ▶Diamox SR (Advanz Pharma) Acetazolamide 250 mg Diamox SR 250mg capsules | 30 capsule P £16.66 DT = £16.66 ▶Eytazox (Teva UK Ltd) Acetazolamide 250 mg Eytazox 250mg modified-release capsules | 30 capsule P £16.60 DT = £16.66

Source page 1267

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

0.25–1 g daily in divided doses, intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1266

Adults

First line only; read the complete Indications and dose section above.

250–500 mg daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1266

Adults

First line only; read the complete Indications and dose section above.

0.25–1 g daily in divided doses, intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1267

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

acetazolamide

Reference monograph

Part of registered formulation

ACETAZOLAMIDE

Reference record: Acetazolamide
Source: BNF 80 (2020–2021)
Printed source pages: 1266, 1267
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Acetazolamide only.

Indications And Dose

Source pages 1266, 1267

Contra Indications

Adrenocortical insufﬁciency. hyperchloraemic acidosis. hypokalaemia. hyponatraemia. long-term administration in chronic angle-closure glaucoma

Source page 1267

Cautions

Source page 1267

Allergy And Cross Sensitivity

Contra-indicated if history of sulfonamide hypersensitivity.

Source page 1267

Safety

Extracted information for Acetazolamide only.

Interactions

→Appendix 1: acetazolamide

Source page 1267

Side Effects

Source page 1267

Pregnancy

Manufacturer advises avoid, especially in ﬁrst trimester (toxicity in animal studies).

Source page 1267

Breast Feeding

Amount too small to be harmful.

Source page 1267

Hepatic Impairment

Manufacturer advises avoid.

Source page 1267

Renal Impairment

Avoid—risk of metabolic acidosis.

Source page 1267

Monitoring Requirements

Monitor blood count and plasma electrolyte concentrations with prolonged use.

Source page 1267

Dose and formulations

Extracted information for Acetazolamide only.

Medicinal Forms

Source page 1267

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

0.25–1 g daily in divided doses, intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1266

Adults

First line only; read the complete Indications and dose section above.

250–500 mg daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1266

Adults

First line only; read the complete Indications and dose section above.

0.25–1 g daily in divided doses, intramuscular

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1267

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.