Individual generic drug information

amikacin

Reference monograph

Part of registered formulation

AMIKACIN SULFATE

Reference record: Amikacin
Source: BNF 80 (2020–2021)
Printed source pages: 566, 567
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Amikacin only.

Indications And Dose

Serious Gram-negative infections resistant to gentamicin (multiple daily dose regimen) ▶BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 15 mg/kg daily in 2 divided doses, increased to 22.5 mg/kg daily in 3 divided doses for up to 10 days, higher dose to be used in severe infections; maximum 1.5 g per day; maximum 15 g per course Serious Gram-negative infections resistant to gentamicin (once daily dose regimen) ▶BY INTRAVENOUS INFUSION ▶Adult: Initially 15 mg/kg once daily (max. per dose 1.5 g once daily), dose to be adjusted according to serum- amikacin concentration; maximum 15 g per course Acute prostatitis (once daily dose regimen) ▶BY INTRAVENOUS INFUSION, OR BY SLOW INTRAVENOUS INJECTION ▶Adult: Initially 15 mg/kg once daily (max. per dose 1.5 g once daily), dose to be adjusted according to serum- amikacin concentration; maximum 15 g per course Acute pyelonephritis (once daily dose regimen) | Urinary tract infection (catheter-associated, once daily dose regimen) ▶BY INTRAVENOUS INFUSION, OR BY SLOW INTRAVENOUS INJECTION ▶Adult: Initially 15 mg/kg once daily (max. per dose 1.5 g once daily), dose to be adjusted according to serum- amikacin concentration; maximum 15 g per course DOSES AT EXTREMES OF BODY-WEIGHT ▶To avoid excessive dosage in obese patients, use ideal weight for height to calculate dose and monitor serum- amikacin concentration closely

Source page 566

Prescribing And Dispensing Information

Once daily dose regimen not to be used for endocarditis, febrile neutropenia, or meningitis. Consult local guidelines.

Source page 566

Safety

Extracted information for Amikacin only.

Interactions

→Appendix 1: aminoglycosides

Source page 566

Side Effects

▶Uncommon Superinfection ▶Rare or very rare Albuminuria. arthralgia. balance impaired. hypotension. muscle twitching. tremor ▶Frequency not known Apnoea. neuromuscular blockade. paralysis

Source page 566

Monitoring Requirements

▶With intravenous use Multiple daily dose regimen: one-hour (‘peak’) serum concentration should not exceed 30 mg/litre; pre-dose (‘trough’) concentration should be less than 10 mg/litre. Once daily dose regimen: pre-dose (‘trough’) concentration should be less than 5 mg/litre.

Source page 566

Dose and formulations

Extracted information for Amikacin only.

Directions For Administration

▶With intravenous use For intravenous infusion (Amikin ®); intermittent in Glucose 5% or Sodium chloride 0.9%. To be given over 30 minutes.

Source page 566

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: solution for injection Solution for injection ▶Amikacin (Non-proprietary) Amikacin (as Amikacin sulfate) 250 mg per 1 ml Amikacin 500mg/2ml solution for injection vials | 5 vial P £60.00 (Hospital only) ▶Amikin (Vianex S.A.) Amikacin (as Amikacin sulfate) 50 mg per 1 ml Amikin 100mg/2ml solution for injection vials | 5 vial P £10.33 eiiii F 543

Source pages 566, 567

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

15 mg/kg daily in 2 divided doses, increased to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Adults

First line only; read the complete Indications and dose section above.

Initially 15 mg/kg once daily (max. per dose 1.5 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Adults

First line only; read the complete Indications and dose section above.

Initially 15 mg/kg once daily (max. per dose 1.5 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Adults

First line only; read the complete Indications and dose section above.

Initially 15 mg/kg once daily (max. per dose 1.5 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

amikacin

Reference monograph

Part of registered formulation

AMIKACIN SULFATE

Reference record: Amikacin
Source: BNF 80 (2020–2021)
Printed source pages: 566, 567
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Amikacin only.

Indications And Dose

Source page 566

Prescribing And Dispensing Information

Once daily dose regimen not to be used for endocarditis, febrile neutropenia, or meningitis. Consult local guidelines.

Source page 566

Safety

Extracted information for Amikacin only.

Interactions

→Appendix 1: aminoglycosides

Source page 566

Side Effects

▶Uncommon Superinfection ▶Rare or very rare Albuminuria. arthralgia. balance impaired. hypotension. muscle twitching. tremor ▶Frequency not known Apnoea. neuromuscular blockade. paralysis

Source page 566

Monitoring Requirements

Source page 566

Dose and formulations

Extracted information for Amikacin only.

Directions For Administration

▶With intravenous use For intravenous infusion (Amikin ®); intermittent in Glucose 5% or Sodium chloride 0.9%. To be given over 30 minutes.

Source page 566

Medicinal Forms

Source pages 566, 567

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

15 mg/kg daily in 2 divided doses, increased to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Adults

First line only; read the complete Indications and dose section above.

Initially 15 mg/kg once daily (max. per dose 1.5 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Adults

First line only; read the complete Indications and dose section above.

Initially 15 mg/kg once daily (max. per dose 1.5 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Adults

First line only; read the complete Indications and dose section above.

Initially 15 mg/kg once daily (max. per dose 1.5 g

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 566

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.