Drug Action
Amlodipine is a dihydropyridine calcium- channel blocker.
Source page 190
Loading InternPractice…
Individual generic drug information
Extracted information for Amlodipine only.
Amlodipine is a dihydropyridine calcium- channel blocker.
Source page 190
Prophylaxis of angina ▶BY MOUTH ▶Adult: Initially 5 mg once daily; maximum 10 mg per day Hypertension ▶BY MOUTH ▶Adult: Initially 5 mg once daily; maximum 10 mg per day DOSE EQUIVALENCE AND CONVERSION ▶Tablets from various suppliers may contain different salts (e.g. amlodipine besilate, amlodipine maleate, and amlodipine mesilate) but the strength is expressed in terms of amlodipine (base); tablets containing different salts are considered interchangeable.
Source page 190
Cardiogenic shock. significant aortic stenosis. unstable angina
Source page 190
Extracted information for Amlodipine only.
SAFE PRACTICE Amlodipine has been confused with nimodipine and atenolol; care must be taken to ensure the correct drug is prescribed and dispensed.
Source page 190
→Appendix 1: calcium channel blockers
Source page 190
▶Common or very common Asthenia. constipation. diarrhoea. dyspepsia. dyspnoea. gastrointestinal disorders. joint disorders. muscle cramps. oedema. vision disorders ▶Uncommon Alopecia. anxiety. arrhythmias. chest pain. cough. dry mouth. gynaecomastia. hyperhidrosis. hypotension. insomnia. malaise. mood altered. numbness. pain. rhinitis. taste altered. tinnitus. tremor. urinary disorders. weight changes ▶Rare or very rare Confusion. hepatic disorders. hyperglycaemia. hypersensitivity. leucopenia. muscle tone increased. myocardial infarction. pancreatitis. peripheral neuropathy. photosensitivity reaction. Stevens-Johnson syndrome. thrombocytopenia. vasculitis ▶Frequency not known Extrapyramidal symptoms. pulmonary oedema
Source page 190
No information available—manufacturer advises avoid, but risk to fetus should be balanced against risk of uncontrolled maternal hypertension.
Source page 190
Manufacturer advises avoid—no information available.
Source page 190
Dose adjustments Manufacturer advises initiate at low dose and titrate slowly (limited information available).
Source page 190
Extracted information for Amlodipine only.
Tablets may be dispersed in water.
Source page 190
There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Oral solution ▶Amlodipine (Non-proprietary) Amlodipine 1 mg per 1 ml Amlodipine 5mg/5ml oral solution sugar- free | 150 ml P £75.78 DT = £75.78 Amlodipine 2 mg per 1 ml Amlodipine 10mg/5ml oral solution sugar-free | 150 ml P £115.73 DT = £115.73 Oral suspension ▶Amlodipine (Non-proprietary) Amlodipine 1 mg per 1 ml Amlodipine 5mg/5ml oral suspension sugar-free | 150 ml P £70.00 DT = £70.00 Tablet ▶Amlodipine (Non-proprietary) Amlodipine 2.5 mg Amlodipine 2.5mg tablets | 28 tablet P £4.50 Amlodipine 5 mg Amlodipine 5mg tablets | 28 tablet P £9.99 DT = £0.84 | 500 tablet P £9.87–£14.82 Amlodipine 10 mg Amlodipine 10mg tablets | 28 tablet P £14.07 DT = £0.86 | 500 tablet P £10.17–£15.54 ▶Istin (Upjohn UK Ltd) Amlodipine 5 mg Istin 5mg tablets | 28 tablet P £11.08 DT = £0.84 Amlodipine 10 mg Istin 10mg tablets | 28 tablet P £16.55 DT = £0.86 Combinations available: Olmesartan with amlodipine, p. 189. Olmesartan with amlodipine and hydrochlorothiazide, p. 189
Source page 190
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
Initially 5 mg once daily; maximum 10 mg per
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 190
First line only; read the complete Indications and dose section above.
Initially 5 mg once daily; maximum 10 mg per
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 190