Therapeutic Action
Penicillin antibacterial
Source page 383
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Individual generic drug information
Extracted information for CLOXACILLIN only.
Penicillin antibacterial
Source page 383
Severe infections due to streptococci and/or staphylococci: meningitis, pneumonia, omphalitis, septicaemia of cutaneous origin, endocarditis, osteomyelitis, necrotizing skin and soft tissues infections, etc. Erysipelas, cellulitis
Source page 383
Extracted information for CLOXACILLIN only.
Do not administer to penicillin-allergic patients. Administer with caution to patients with allergy to cephalosporins (cross-sensitivity may occur) or with renal impairment (reduce the dose). May cause: gastrointestinal disturbances (particularly diarrhoea), allergic reactions sometimes severe; rarely, haematological disorders. Do not combine with methotrexate (increased methotrexate toxicity). Pregnancy and breast-feeding: no contra-indication
Source page 384
Extracted information for CLOXACILLIN only.
Powder for injection, in 500 mg vial, to be dissolved in 4 ml of water for injection, for IV infusion in 0.9% sodium chloride or 5% glucose, to be administered in 60 minutes
Source page 383
Severe infections Neonate: 0 to 7 days (< 2 kg): 50 mg/kg every 12 hours 0 to 7 days (≥ 2 kg): 50 mg/kg every 8 hours 8 days to < 1 month (< 2 kg): 50 mg/kg every 8 hours 8 days to < 1 month (≥ 2 kg): 50 mg/kg every 6 hours Child 1 month and over: 25 to 50 mg/kg (max. 2 g) every 6 hours Adult: 2 g every 6 hours 500 mg vial Age Weight (diluted in 4 ml, 125 mg/ml) 1 to < 3 months 4 to < 6 kg 1 ml x 4 3 months to < 1 year 6 to < 10 kg 2 ml x 4 1 to < 5 years 10 to < 20 kg 4 ml x 4 (1 vial x 4) 5 to < 8 years 20 to < 28 kg 8 ml x 4 (2 vials x 4) 8 to < 12 years 28 to < 38 kg 12 ml x 4 (3 vials x 4) ≥ 12 years and adult ≥ 38 kg 16 ml x 4 (4 vials x 4) Dilute each dose of cloxacillin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults. Erysipelas, cellulitis Neonate, child and adult: half of above dose
Source pages 383, 384
Change to oral route as soon as possible with amoxicillin/clavulanic acid or cefalexin depending on the indication. Do not use oral cloxacillin for completion treatment following parenteral therapy.
Source page 384
Extracted information for CLOXACILLIN only.
Dicloxacillin, flucloxacillin and oxacillin are used for the same indications. Do not mix with other drugs in the same infusion.
Source page 384
– Below 25 °C Reconstituted solution must be used immediately.
Source pages 384, 385
Filter the extracted dose blocks for this individual drug.
25 to 50 mg/kg (max. 2 g) every 6 hours
Candidate age grouping · source page 383
2 g every 6 hours
Candidate age grouping · source page 383
half of above dose
Candidate age grouping · source page 384