Individual generic drug information

atorvastatin

Reference monograph

Part of registered formulation

ATORVASTATIN CALCIUM TRIHYDRATE

Reference record: Atorvastatin
Source: BNF 80 (2020–2021)
Printed source pages: 237
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Atorvastatin only.

Indications And Dose

Primary hypercholesterolaemia in patients who have not responded adequately to diet and other appropriate measures | Combined (mixed) hyperlipidaemia in patients who have not responded adequately to diet and other appropriate measures ▶BY MOUTH ▶Adult: Usual dose 10 mg once daily; increased if necessary up to 80 mg once daily, dose to be increased at intervals of at least 4 weeks Heterozygous familial hypercholesterolaemia in patients who have not responded adequately to diet and other appropriate measures | Homozygous familial hypercholestrolaemia in patients who have not responded adequately to diet and other appropriate measures ▶BY MOUTH ▶Adult: Initially 10 mg once daily, then increased to 40 mg once daily, dose to be increased at intervals of at least 4 weeks; maximum 80 mg per day Primary prevention of cardiovascular events in patients at high risk of a first cardiovascular event ▶BY MOUTH ▶Adult: 20 mg once daily, dose can be increased if necessary Secondary prevention of cardiovascular events ▶BY MOUTH ▶Adult: 80 mg once daily

Source page 237

Dose Adjustments

DUE TO INTERACTIONS ▶Manufacturer advises if concurrent use of ciclosporin is unavoidable, max. dose cannot exceed 10 mg daily. ▶Manufacturer advises max. dose 40 mg daily when combined with anion-exchange resin for heterozygous familial hypercholesterolaemia. ▶Manufacturer advises max. dose 20 mg daily with concurrent use of elbasvir with grazoprevir. ▶Manufacturer advises max. dose 20 mg daily with concurrent use of letermovir without ciclosporin. ▶Manufacturer advises max. dose 20 mg daily with concurrent use of sofosbuvir with velpatasvir and voxilaprevir. l UNLICENSED USE g Not licensed for secondary prevention of cardiovascular events. Starting dose of 20 mg once daily is not licensed for the primary prevention of cardiovascular events. h

Source page 237

Cautions

Haemorrhagic stroke

Source page 237

Safety

Extracted information for Atorvastatin only.

Interactions

→Appendix 1: statins

Source page 237

Side Effects

▶Common or very common Epistaxis. hyperglycaemia. hypersensitivity. joint disorders. laryngeal pain. muscle complaints. nasopharyngitis. pain ▶Uncommon Appetite decreased. burping. chest pain. fever . hypoglycaemia. malaise. numbness. peripheral oedema. taste altered. tinnitus. vision disorders. weight increased ▶Rare or very rare Angioedema. gynaecomastia. hearing loss. severe cutaneous adverse reactions (SCARs)

Source page 237

Breast Feeding

Manufacturer advises avoid—no information available.

Source page 237

Renal Impairment

Dose adjustments In chronic kidney disease, for primary Cardiovascular system and secondary prevention of cardiovascular events [unlicensed starting dose in primary prevention; unlicensed in secondary prevention], initially 20 mg once daily, increased if necessary (on specialist advice if eGFR < 30 mL/minute/1.73 m2); max. 80 mg once daily.

Source page 237

Dose and formulations

Extracted information for Atorvastatin only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet ▶Atorvastatin (Non-proprietary) Atorvastatin (as Atorvastatin calcium trihydrate) 10 mg Atorvastatin 10mg tablets | 28 tablet P £13.00 DT = £0.89 | 90 tablet P £41.78 | 500 tablet P £9.72 Atorvastatin (as Atorvastatin calcium trihydrate) 20 mg Atorvastatin 20mg tablets | 28 tablet P £24.64 DT = £1.03 | 90 tablet P £79.20 | 500 tablet P £11.69 Atorvastatin (as Atorvastatin calcium trihydrate) 30 mg Atorvastatin 30mg tablets | 28 tablet P £24.51 DT = £24.51 Atorvastatin (as Atorvastatin calcium trihydrate) 40 mg Atorvastatin 40mg tablets | 28 tablet P £24.64 DT = £1.29 | 90 tablet P £79.20 | 500 tablet P £14.42 Atorvastatin (as Atorvastatin calcium trihydrate) 60 mg Atorvastatin 60mg tablets | 28 tablet P £28.01 DT = £28.01 Atorvastatin (as Atorvastatin calcium trihydrate) 80 mg Atorvastatin 80mg tablets | 28 tablet P £28.21 DT = £1.90 | 90 tablet P £90.67 ▶Lipitor (Upjohn UK Ltd) Atorvastatin (as Atorvastatin calcium trihydrate) 10 mg Lipitor 10mg tablets | 28 tablet P £13.00 DT = £0.89 Atorvastatin (as Atorvastatin calcium trihydrate) 20 mg Lipitor 20mg tablets | 28 tablet P £24.64 DT = £1.03 Atorvastatin (as Atorvastatin calcium trihydrate) 40 mg Lipitor 40mg tablets | 28 tablet P £24.64 DT = £1.29 Atorvastatin (as Atorvastatin calcium trihydrate) 80 mg Lipitor 80mg tablets | 28 tablet P £28.21 DT = £1.90 Chewable tablet CAUTIONARY AND ADVISORY LABELS 24 ▶Lipitor (Upjohn UK Ltd) Atorvastatin (as Atorvastatin calcium trihydrate) 10 mg Lipitor 10mg chewable tablets sugar-free | 30 tablet P £13.80 DT = £13.80 Atorvastatin (as Atorvastatin calcium trihydrate) 20 mg Lipitor 20mg chewable tablets sugar-free | 30 tablet P £26.40 DT = £26.40 eiiii F 214

Source page 237

Clinical care

Extracted information for Atorvastatin only.

Patient And Carer Advice

Patient counselling is advised for atorvastatin tablets (muscle effects).

Source page 237

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Usual dose 10 mg once daily; increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Adults

First line only; read the complete Indications and dose section above.

Initially 10 mg once daily, then increased to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Adults

First line only; read the complete Indications and dose section above.

20 mg once daily, dose can be increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Adults

First line only; read the complete Indications and dose section above.

80 mg once daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

atorvastatin

Reference monograph

Part of registered formulation

ATORVASTATIN CALCIUM TRIHYDRATE

Reference record: Atorvastatin
Source: BNF 80 (2020–2021)
Printed source pages: 237
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Atorvastatin only.

Indications And Dose

Source page 237

Dose Adjustments

Source page 237

Cautions

Haemorrhagic stroke

Source page 237

Safety

Extracted information for Atorvastatin only.

Interactions

→Appendix 1: statins

Source page 237

Side Effects

Source page 237

Breast Feeding

Manufacturer advises avoid—no information available.

Source page 237

Renal Impairment

Source page 237

Dose and formulations

Extracted information for Atorvastatin only.

Medicinal Forms

Source page 237

Clinical care

Extracted information for Atorvastatin only.

Patient And Carer Advice

Patient counselling is advised for atorvastatin tablets (muscle effects).

Source page 237

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Usual dose 10 mg once daily; increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Adults

First line only; read the complete Indications and dose section above.

Initially 10 mg once daily, then increased to

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Adults

First line only; read the complete Indications and dose section above.

20 mg once daily, dose can be increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Adults

First line only; read the complete Indications and dose section above.

80 mg once daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 237

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.