Therapeutic Action
Macrolide antibacterial
Source page 51
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Individual generic drug information
Extracted information for AZITHROMYCIN only.
Macrolide antibacterial
Source page 51
Trachoma, conjunctivitis due to Chlamydia trachomatis Cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for gonorrhoea), donovanosis, chancroid, early syphilis Cholera (if the strain is susceptible), typhoid fever, yaws, leptospirosis, louse-borne and tick-borne relapsing fevers Pertussis, diphtheria, pneumonia due to Mycoplasma pneumoniae and Chlamydophila pneumoniae Second-line treatment of shigellosis Streptococcal tonsillitis, acute otitis media, in penicillin-allergic patients only
Source page 51
Extracted information for AZITHROMYCIN only.
Do not administer to patients with allergy to azithromycin or another macrolide, and to patients with severe hepatic impairment. Administer with caution to children under 6 weeks of age (risk of hypertrophic pyloric stenosis) and patients with risk factors for QT prolongation (e.g. electrolyte disturbances, pre-existing cardiac and renal disorders, older patients). May cause: gastrointestinal disturbances, reversible hearing disorders, electrolytes disturbances, QT prolongation; rarely: hypersensitivity reactions (including severe cutaneous reactions such as Stevens- Johnson, Lyell and DRESS syndromes) and life-threatening hepatotoxicity. In these cases, stop treatment. Signs and symptoms of hypersensitivity reaction (e.g. fever, rash, mouth ulcers, bleeding) and hepatic disorders (e.g. anorexia, nausea, general malaise, dark urine, pale stools, hepatomegaly, jaundice) require immediate medical attention. Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.). Administer 2 hours apart. Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, co- artemether, fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine, quinine, etc.). Administer with caution and monitor use in patients taking digoxin (increased digoxin toxicity plasma levels). Pregnancy and breast-feeding: no contra-indication
Source pages 52, 53
Extracted information for AZITHROMYCIN only.
250 mg and 500 mg tablets 200 mg/5 ml powder for oral suspension, to be reconstituted with filtered water
Source page 51
Trachoma, cholera, cervicitis and urethritis due to C. trachomatis, chancroid, early syphilis Child: 20 mg/kg (max. 1 g) single dose Adult: 1 g single dose (2 g single dose in early syphilis) Yaws Child and adult: 30 mg/kg (max. 2 g) single dose Conjunctivitis due to C. trachomatis Child: 20 mg/kg (max. 1 g) once daily for 3 days Adult: 1 g once daily for 3 days Typhoid fever Child: 10 to 20 mg/kg (max. 1 g) once daily for 7 days Adult: 500 mg to 1 g once daily for 7 days or 1 g on D1 then 500 mg once daily from D2 to D7 Donovanosis (granuloma inguinale) Adult: 1 g on D1 then 500 mg once daily until healing of lesions Pertussis Child under 6 months: 10 mg/kg once daily for 5 days Child 6 months and over: 10 mg/kg (max. 500 mg) on D1 then 5 mg/kg (max. 250 mg) once daily from D2 to D5 Adult: 500 mg on D1 then 250 mg once daily from D2 to D5 Pneumonia due to M. pneumoniae and C. pneumoniae Child: 10 mg/kg (max. 500 mg) once daily for 5 days Adult: 500 mg on D1 then 250 mg once daily from D2 to D5 Leptospirosis Child: 10 mg/kg (max. 500 mg) on D1 then 5 mg/kg (max. 250 mg) once daily on D2 and D3 Adult: 1 g on D1 then 500 mg once daily on D2 and D3 Shigellosis Child: 12 mg/kg (max. 500 mg) on D1 then 6 mg/kg (max. 250 mg) once daily from D2 to D5 Adult: 500 mg on D1 then 250 mg once daily from D2 to D5 Diphtheria Child: 10 to 12 mg/kg (max. 500 mg) once daily for 14 days Adult: 500 mg once daily for 14 days Relapsing fevers (louse-borne and tick-borne) Child: 10 mg/kg (max. 500 mg) single dose for louse-borne relapsing fever and once daily for 7 to 10 days for tick-borne relapsing fever Adult: 500 mg single dose for louse-borne relapsing fever and once daily for 7 to 10 days for tick- borne relapsing fever Streptococcal tonsillitis, only in penicillin-allergic patients Child: 20 mg/kg (max. 500 mg) once daily for 3 days Adult: 500 mg once daily for 3 days Acute otitis media, only in penicillin-allergic patients Child: 10 mg/kg (max. 500 mg) once daily for 3 days
Source pages 51, 52
Extracted information for AZITHROMYCIN only.
Azithromycin is also used for septicaemia of pulmonary or gynaecological origin (child: 10 to 20 mg/kg (max. 1 g) once daily; adult: 500 mg to 1 g once daily), in combination with other antibacterials. Also comes in 250 mg or 500 mg capsules, to be taken one hour before or 2 hours after a meal.
Source page 53
- - Below 25 °C For the oral suspension (powder or reconstituted suspension): follow manufacturer’s instructions.
Source page 53
Filter the extracted dose blocks for this individual drug.
20 mg/kg (max. 1 g) single dose
Candidate age grouping · source page 51
1 g single dose (2 g single dose in early syphilis)
Candidate age grouping · source page 51
30 mg/kg (max. 2 g) single dose
Candidate age grouping · source page 51
20 mg/kg (max. 1 g) once daily for 3 days
Candidate age grouping · source page 51
1 g once daily for 3 days
Candidate age grouping · source page 51
10 to 20 mg/kg (max. 1 g) once daily for 7 days
Candidate age grouping · source page 51
500 mg to 1 g once daily for 7 days or 1 g on D1 then 500 mg once daily from D2 to D7
Candidate age grouping · source page 51
1 g on D1 then 500 mg once daily until healing of lesions
Candidate age grouping · source page 52
10 mg/kg once daily for 5 days
Candidate age grouping · source page 52
10 mg/kg (max. 500 mg) on D1 then 5 mg/kg (max. 250 mg) once daily from D2 to D5
Candidate age grouping · source page 52
500 mg on D1 then 250 mg once daily from D2 to D5
Candidate age grouping · source page 52
10 mg/kg (max. 500 mg) once daily for 5 days
Candidate age grouping · source page 52
500 mg on D1 then 250 mg once daily from D2 to D5
Candidate age grouping · source page 52
10 mg/kg (max. 500 mg) on D1 then 5 mg/kg (max. 250 mg) once daily on D2 and D3
Candidate age grouping · source page 52
1 g on D1 then 500 mg once daily on D2 and D3
Candidate age grouping · source page 52
12 mg/kg (max. 500 mg) on D1 then 6 mg/kg (max. 250 mg) once daily from D2 to D5
Candidate age grouping · source page 52
500 mg on D1 then 250 mg once daily from D2 to D5
Candidate age grouping · source page 52
10 to 12 mg/kg (max. 500 mg) once daily for 14 days
Candidate age grouping · source page 52
500 mg once daily for 14 days
Candidate age grouping · source page 52
10 mg/kg (max. 500 mg) single dose for louse-borne relapsing fever and once daily for 7 to 10 days for tick-borne relapsing fever
Candidate age grouping · source page 52
500 mg single dose for louse-borne relapsing fever and once daily for 7 to 10 days for tick- borne relapsing fever
Candidate age grouping · source page 52
20 mg/kg (max. 500 mg) once daily for 3 days
Candidate age grouping · source page 52
500 mg once daily for 3 days
Candidate age grouping · source page 52
10 mg/kg (max. 500 mg) once daily for 3 days
Candidate age grouping · source page 52