Names and pronunciation
(bed-ak′-wi-leen) Sirturo
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Individual generic drug information
Extracted information for bedaquiline only.
(bed-ak′-wi-leen) Sirturo
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Func. class.: Antiinfective/antituber- culotic
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USES: For use as part of a combina- tion regimen to treat pulmonary multi- drug-resistant tuberculosis infection (MDR-TB) in adults/children when other effective treatment regimens are not available
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Extracted information for bedaquiline only.
CONTRAINDICATIONS: Hyper- sensitivity Precautions: Alcoholism, bradycar- dia, breastfeeding, arrhythmias, cardiac disease, children, coronary artery dis- ease, diabetes mellitus, females, geriat- ric patients, heart failure, hepatic dis- ease, hypertension, hypocalcemia, hypokalemia, hypomagnesemia, malnu- trition, MI, pregnancy, syncope, thyroid disease
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Black Box Warning: QT prolongation, increased mortality risk
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Extracted information for bedaquiline only.
DOSAGE AND ROUTES • Adults/child ≥ 5 yr and ≥30 kg: PO 400 mg daily × 2 wk, then reduce dose to 200 mg 3×/wk with food (≥48 hr between doses). Total duration is 24 wk • Child ≥5 yr and 15-30 kg: PO 200 mg daily for 2 wk, then 100 mg 3 times a week spaced 48 hr apart for 22 wk, total duration 24 wk
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Available forms: Tablets 20, 100 mg
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Filter the extracted dose blocks for this individual drug.
• Adults/child ≥ 5 yr and ≥30 kg: PO 400 mg daily × 2 wk, then reduce dose to 200 mg 3×/wk with food (≥48 hr between doses). Total duration is 24 wk
Candidate age grouping · source page 148
• Child ≥5 yr and 15-30 kg: PO 200 mg daily for 2 wk, then 100 mg 3 times a week spaced 48 hr apart for 22 wk, total duration 24 wk
Candidate age grouping · source page 148