Therapeutic Action
Aminoglycoside antibacterial
Source page 406
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Individual generic drug information
Extracted information for GENTAMICIN only.
Aminoglycoside antibacterial
Source page 406
Severe bacterial infections: plague, septicaemia, meningitis, pneumonia, pyelonephritis, postpartum upper genital tract infections, brucellosis, etc., in combination with other antibacterials
Source page 406
Extracted information for GENTAMICIN only.
Do not administer to patients with allergy to aminoglycosides. Administer with caution to patients with history of renal, vestibular or auditory problems. Reduce dosage in patients with renal impairment. May cause: irreversible ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade; rarely, allergic reactions. Stop treatment in the event of dizziness, tinnitus or hearing loss (ototoxicity). Do not combine with another aminoglycoside. Avoid or monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditory toxicity); neuromuscular blockers (increased neuromuscular blockage). Pregnancy: administer only if clearly needed (risk of fetal ototoxicity). Breast-feeding: no contra-indication
Source page 407
Extracted information for GENTAMICIN only.
10 mg in 1 ml ampoule (10 mg/ml) and 80 mg in 2 ml ampoule (40 mg/ml) for IM or slow IV injection (3 minutes) or IV infusion (30 minutes) in 0.9% sodium chloride or 5% glucose
Source page 406
Meningitis in young children, in combination with ampicillin or cloxacillin Neonate: 0 to 7 days (< 2 kg): 3 mg/kg once daily by IV injection or infusion 0 to 7 days (≥ 2 kg): 5 mg/kg once daily by IV injection or infusion 8 days to < 1 month: 5 mg/kg once daily by IV injection or infusion Child 1 to 3 months: 2.5 mg/kg every 8 hours by IV injection or infusion Other severe bacterial infections Neonate : as above Child 1 month and over: 4.5 to 7.5 mg/kg once daily Adult: 5 to 6 mg/kg once daily For administration by IV infusion, dilute each dose of gentamicin in 5 ml/kg of 0.9% sodium chloride or 5% glucose in children less than 20 kg and in a bag of 100 ml of 0.9% sodium chloride or 5% glucose in children 20 kg and over and in adults.
Source page 406
Plague: 10 to 14 days Other infections: according to indication and clinical response
Source pages 406, 407
Extracted information for GENTAMICIN only.
Do not mix with other drugs in the same syringe or infusion.
Source page 407
– Below 25 °C
Source page 407
Filter the extracted dose blocks for this individual drug.
2.5 mg/kg every 8 hours by IV injection or infusion
Candidate age grouping · source page 406
as above
Candidate age grouping · source page 406
4.5 to 7.5 mg/kg once daily
Candidate age grouping · source page 406
5 to 6 mg/kg once daily
Candidate age grouping · source page 406