Therapeutic Action
Cardioselective beta-blocker
Source page 63
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Individual generic drug information
Extracted information for BISOPROLOL only.
Cardioselective beta-blocker
Source page 63
Hypertension, treatment of chronic stable angina pectoris Chronic stable heart failure in combination with a converting enzyme inhibitor (enalapril)
Source page 63
Extracted information for BISOPROLOL only.
Do not administer to patients with asthma, chronic obstructive bronchopneumonia, acute heart failure, severe hypotension, bradycardia < 50/minute, atrio-ventricular heart blocks, Raynaud's syndrome. May cause: bradycardia, hypotension, worsening of heart failure (reduce dose); bronchospasm in patients with an obstructive respiratory disease; hypoglycaemia, gastrointestinal disturbances, headache, fatigue, muscle weakness, erectile dysfunction. Administer with caution to patients with diabetes (risk of hypoglycaemia). In the event of anaphylactic shock, risk of resistance to epinephrine. Avoid or monitor combination with: mefloquine, digoxin, amiodarone, diltiazem, verapamil (risk of bradycardia); tricyclic antidepressants, antipsychotics, anti-hypertensive drugs (risk of hypotension). Pregnancy and breast-feeding: use labetalol, particularly for the management of hypertension in pregnancy.
Source page 64
Extracted information for BISOPROLOL only.
2.5 mg breakable tablet 10 mg breakable in ¼ tablet
Source page 63
Hypertension, angina pectoris Adult: 5 to 10 mg once daily, preferably in the morning (max. 20 mg daily) In patients with renal or hepatic impairment: start with 2.5 mg once daily then increase, if necessary, according to clinical response (max. 10 mg daily) Heart failure Adult: start with 1.25 mg once daily and increase according to the table below, as long as the drug is well tolerated (heart rate, blood pressure, signs of worsening heart failure) Weeks Daily dose Tablet(s) Week 1 1.25 mg once daily 2.5 mg tab: ½ tab daily 2.5 mg tab: 1 tab daily Week 2 2.5 mg once daily or 10 mg tab: ¼ tab daily Week 3 3.75 mg once daily 2.5 mg tab: 1½ tab daily Week 4 to 8 5 mg once daily 10 mg tab: ½ tab daily 2.5 mg tab: 1 tab daily + 10 mg tab: ½ tab daily Week 9 to 12 7.5 mg once daily or 10 mg tab: ¾ tab daily 10 mg once daily From week 13 10 mg tab: 1 tab daily (max. 10 mg daily)
Source pages 63, 64
According to clinical response. Do not stop treatment abruptly, decrease doses gradually.
Source page 64
Extracted information for BISOPROLOL only.
– – Below 25 °C
Source pages 64, 65
Filter the extracted dose blocks for this individual drug.
5 to 10 mg once daily, preferably in the morning (max. 20 mg daily)
Candidate age grouping · source page 63
start with 1.25 mg once daily and increase according to the table below, as long as the drug is well tolerated (heart rate, blood pressure, signs of worsening heart failure)
Candidate age grouping · source page 63