Therapeutic Action
Specific opioid antagonist
Source page 461
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Individual generic drug information
Extracted information for NALOXONE only.
Specific opioid antagonist
Source page 461
Respiratory depression induced by opioids (analgesia, anaesthesia, intoxication)
Source page 461
Extracted information for NALOXONE only.
tachycardia, fibrillation, hypertension, pulmonary oedema when given postoperatively, due to a sudden reversal of analgesia; nausea, vomiting; acute withdrawal syndrome in opioid-dependent patients. Administer with caution and reduce dosage in case of heart failure or coronary artery disease. Naloxone is used in addition to assisted ventilation and must be administered under close medical supervision. Pregnancy: risks linked to respiratory depression appear greater than risks linked to naloxone. Breast-feeding: no contra-indication
Source pages 461, 462
Extracted information for NALOXONE only.
0.4 mg in 1 ml ampoule (0.4 mg/ml) for IV, IM injection or infusion in sodium chloride 0.9% or glucose 5%
Source page 461
IV route is preferred, use IM route if IV route is not feasible: Child: 5 to 10 micrograms/kg by IV injection, repeated if necessary after 2 to 3 minutes, until adequate spontaneous ventilation is restored, followed by a continuous infusion of 1 to 5 micrograms/kg/hour, or by 5 to 10 micrograms/kg by IM injection every 90 minutes Adult: 1 to 3 micrograms/kg by IV injection, repeated if necessary after 2 to 3 minutes, until adequate spontaneous ventilation is restored, followed by a continuous infusion of 1 to 5 micrograms/kg/hour, or by 5 to 10 micrograms/kg by IM injection every 90 minutes
Source page 461
The duration of action of naloxone (20 to 30 minutes by IV route) is shorter than that of opioids: administration must be maintained several hours even if breathing improves.
Source page 461
Extracted information for NALOXONE only.
Naloxone is a specific opioid antidote. It cannot be used to antagonise the effects of other drugs producing CNS or respiratory depression. Efficacy in antagonising opioid effects depends not only on the dose of naloxone but also on the dose and potency of the specific opioid involved.
Source page 462
– Below 25 °C
Source page 462
Filter the extracted dose blocks for this individual drug.
5 to 10 micrograms/kg by IV injection, repeated if necessary after 2 to 3 minutes, until adequate spontaneous ventilation is restored, followed by a continuous infusion of 1 to 5 micrograms/kg/hour, or by 5 to 10 micrograms/kg by IM injection every 90 minutes
Candidate age grouping · source page 461
1 to 3 micrograms/kg by IV injection, repeated if necessary after 2 to 3 minutes, until adequate spontaneous ventilation is restored, followed by a continuous infusion of 1 to 5 micrograms/kg/hour, or by 5 to 10 micrograms/kg by IM injection every 90 minutes
Candidate age grouping · source page 461