Individual generic drug information

calcitriol

Reference monograph

Part of registered formulation

CALCITRIOL

Reference record: Calcitriol
Source: BNF 80 (2020–2021)
Printed source pages: 1166, 1167
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Calcitriol only.

Indications And Dose

Renal osteodystrophy ▶BY MOUTH ▶Adult: Initially 250 nanograms daily, adjusted in steps of 250 nanograms every 2–4 weeks if required; usual dose 0.5–1 microgram daily Renal osteodystrophy (in patients with normal or only slightly reduced plasma-calcium concentration) ▶BY MOUTH ▶Adult: Initially 250 nanograms once daily on alternate days, adjusted in steps of 250 nanograms every 2–4 weeks if required; usual dose 0.5–1 microgram daily Established postmenopausal osteoporosis ▶BY MOUTH ▶Adult: 250 nanograms twice daily, plasma-calcium concentration and creatinine to be monitored (consult product literature)

Source page 1166

Safety

Extracted information for Calcitriol only.

Interactions

→Appendix 1: vitamin D substances

Source page 1166

Side Effects

▶Common or very common Urinary tract infection ▶Frequency not known Abdominal pain upper. apathy. arrhythmia. dehydration. drowsiness. fever. growth retardation. muscle weakness. paralytic ileus. polydipsia. psychiatric disorder. sensory disorder. urinary disorders. weight decreased

Source page 1166

Renal Impairment

Manufacturer advises avoid—no information available. Monitoring Monitor plasma-calcium concentration in renal impairment.

Source pages 1166, 1167

Monitoring Requirements

▶Monitor plasma calcium, phosphate, and creatinine during dosage titration. ▶Monitor plasma-calcium concentration in patients receiving high doses.

Source page 1167

Dose and formulations

Extracted information for Calcitriol only.

Directions For Administration

Contents of capsule may be administered by oral syringe.

Source page 1167

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Oral solution ▶Rocaltrol (Imported (Switzerland)) Calcitriol 1 microgram per 1 ml Rocaltrol 1micrograms/ml oral solution sugar-free | 10 ml P s Capsule ▶Calcitriol (Non-proprietary) Calcitriol 250 nanogram Calcitriol 250nanogram capsules | 30 capsule P £5.41–£18.04 Calcitriol 500 nanogram Calcitriol 500nanogram capsules | 30 capsule P £32.25 ▶Rocaltrol (Roche Products Ltd) Calcitriol 250 nanogram Rocaltrol 250nanogram capsules | 100 capsule P £18.04 DT = £18.04 Calcitriol 500 nanogram Rocaltrol 500nanogram capsules | 100 capsule P £32.25 DT = £32.25 eiiii F 1143

Source page 1167

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 250 nanograms daily, adjusted in steps

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1166

Adults

First line only; read the complete Indications and dose section above.

Initially 250 nanograms once daily on alternate

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1166

Adults

First line only; read the complete Indications and dose section above.

250 nanograms twice daily, plasma-calcium

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1166

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

calcitriol

Reference monograph

Part of registered formulation

CALCITRIOL

Reference record: Calcitriol
Source: BNF 80 (2020–2021)
Printed source pages: 1166, 1167
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Calcitriol only.

Indications And Dose

Source page 1166

Safety

Extracted information for Calcitriol only.

Interactions

→Appendix 1: vitamin D substances

Source page 1166

Side Effects

Source page 1166

Renal Impairment

Manufacturer advises avoid—no information available. Monitoring Monitor plasma-calcium concentration in renal impairment.

Source pages 1166, 1167

Monitoring Requirements

▶Monitor plasma calcium, phosphate, and creatinine during dosage titration. ▶Monitor plasma-calcium concentration in patients receiving high doses.

Source page 1167

Dose and formulations

Extracted information for Calcitriol only.

Directions For Administration

Contents of capsule may be administered by oral syringe.

Source page 1167

Medicinal Forms

Source page 1167

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 250 nanograms daily, adjusted in steps

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1166

Adults

First line only; read the complete Indications and dose section above.

Initially 250 nanograms once daily on alternate

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1166

Adults

First line only; read the complete Indications and dose section above.

250 nanograms twice daily, plasma-calcium

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 1166

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.