Individual generic drug information

candesartan cilexetil

Reference monograph

Part of registered formulation

CANDESARTAN CILEXETIL + HYDROCHLOROT HIAZIDE

Reference record: Candesartan cilexetil
Source: BNF 80 (2020–2021)
Printed source pages: 208, 209
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Candesartan cilexetil only.

Indications And Dose

Hypertension ▶BY MOUTH ▶Adult: Initially 8 mg once daily, increased if necessary up to 32 mg once daily, doses to be increased at intervals of 4 weeks; usual dose 8 mg once daily Hypertension with intravascular volume depletion ▶BY MOUTH ▶Adult: Initially 4 mg once daily, increased if necessary up to 32 mg daily, doses to be increased at intervals of 4 weeks; usual dose 8 mg once daily Heart failure with impaired left ventricular systolic function when ACE inhibitors are not tolerated | Heart failure with impaired left ventricular systolic function in conjunction with an ACE inhibitor (under expert supervision) ▶BY MOUTH ▶Adult: Initially 4 mg once daily, increased at intervals of at least 2 weeks to ’target’ dose of 32 mg once daily or to maximum tolerated dose; maximum 32 mg per day Migraine prophylaxis ▶BY MOUTH ▶Adult: 16 mg once daily l UNLICENSED USE g Candesartan is used for migraine prophylaxis, h but is not licensed for this indication.

Source page 208

Contra Indications

Cholestasis

Source page 208

Safety

Extracted information for Candesartan cilexetil only.

Interactions

→Appendix 1: angiotensin-II receptor antagonists

Source page 208

Side Effects

▶Common or very common Increased risk of infection ▶Rare or very rare Agranulocytosis. hepatitis. hyponatraemia. leucopenia. neutropenia

Source page 208

Hepatic Impairment

Manufacturer advises avoid in severe impairment or cholestasis. Dose adjustments Manufacturer advises initial dose reduction to 4 mg once daily in mild to moderate impairment; adjust according to response.

Source page 208

Renal Impairment

Use with caution if eGFR less than 15 mL/minute/1.73 m2—limited experience. Dose adjustments Initially 4 mg daily.

Source page 208

Dose and formulations

Extracted information for Candesartan cilexetil only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension, oral solution Tablet ▶Candesartan cilexetil (Non-proprietary) Candesartan cilexetil 2 mg Candesartan 2mg tablets | 7 tablet P £16.13 DT = £1.23 Candesartan cilexetil 4 mg Candesartan 4mg tablets | 7 tablet P £3.88 DT = £0.79 | 28 tablet P £0.49–£9.78 Candesartan cilexetil 8 mg Candesartan 8mg tablets | 28 tablet P £9.89 DT = £1.68 Candesartan cilexetil 16 mg Candesartan 16mg tablets | 28 tablet P £12.72 DT = £1.71 Candesartan cilexetil 32 mg Candesartan 32mg tablets | 28 tablet P £16.13 DT = £1.94 ▶Amias (Takeda UK Ltd) Candesartan cilexetil 2 mg Amias 2mg tablets | 7 tablet P £3.58 DT = £1.23 Candesartan cilexetil 4 mg Amias 4mg tablets | 7 tablet P £3.88 DT = £0.79 | 28 tablet P £9.78 Candesartan cilexetil 8 mg Amias 8mg tablets | 28 tablet P £9.89 DT = £1.68 Candesartan cilexetil 16 mg Amias 16mg tablets | 28 tablet P £12.72 DT = £1.71 Candesartan cilexetil 32 mg Amias 32mg tablets | 28 tablet P £16.13 DT = £1.94 eiiii F 185

Source pages 208, 209

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 8 mg once daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily, increased at intervals

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Adults

First line only; read the complete Indications and dose section above.

16 mg once daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

candesartan cilexetil

Reference monograph

Part of registered formulation

CANDESARTAN CILEXETIL + HYDROCHLOROT HIAZIDE

Reference record: Candesartan cilexetil
Source: BNF 80 (2020–2021)
Printed source pages: 208, 209
Age groups indexed: 1

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Candesartan cilexetil only.

Indications And Dose

Source page 208

Contra Indications

Cholestasis

Source page 208

Safety

Extracted information for Candesartan cilexetil only.

Interactions

→Appendix 1: angiotensin-II receptor antagonists

Source page 208

Side Effects

▶Common or very common Increased risk of infection ▶Rare or very rare Agranulocytosis. hepatitis. hyponatraemia. leucopenia. neutropenia

Source page 208

Hepatic Impairment

Source page 208

Renal Impairment

Use with caution if eGFR less than 15 mL/minute/1.73 m2—limited experience. Dose adjustments Initially 4 mg daily.

Source page 208

Dose and formulations

Extracted information for Candesartan cilexetil only.

Medicinal Forms

Source pages 208, 209

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

Initially 8 mg once daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily, increased if necessary

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Adults

First line only; read the complete Indications and dose section above.

Initially 4 mg once daily, increased at intervals

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Adults

First line only; read the complete Indications and dose section above.

16 mg once daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 208

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.