Indications And Dose
Hypertension ▶BY MOUTH ▶Adult: Initially 12.5–25 mg twice daily, then increased if necessary up to 150 mg daily in 2 divided doses, doses to be increased at intervals of at least 2 weeks, once-daily dosing may be appropriate if other concomitant antihypertensive drugs taken ▶Elderly: Initially 6.25 mg twice daily, then increased if necessary up to 150 mg daily in 2 divided doses, doses to be increased at intervals of at least 2 weeks, once- daily dosing may be appropriate if other concomitant antihypertensive drugs taken Essential hypertension if used in volume depletion, cardiac decompensation, or renovascular hypertension ▶BY MOUTH ▶Adult: Initially 6.25–12.5 mg for 1 dose (under close medical supervision), then 6.25–12.5 mg twice daily; increased if necessary up to 100 mg daily in 1–2 divided doses, doses to be increased at intervals of at least 2 weeks, once-daily dosing may be appropriate if other concomitant antihypertensive drugs taken Heart failure ▶BY MOUTH ▶Adult (under close medical supervision): Initially 6.25–12.5 mg 2–3 times a day, then increased if tolerated to up to 150 mg daily in divided doses, dose to be increased gradually at intervals of at least 2 weeks Short-term treatment within 24 hours of onset of myocardial infarction in clinically stable patients ▶BY MOUTH ▶Adult: Initially 6.25 mg, then increased to 12.5 mg after 2 hours, followed by 25 mg after 12 hours; increased if continued → tolerated to 50 mg twice daily for 4 weeks Prophylaxis of symptomatic heart failure after myocardial infarction in clinically stable patients with asymptomatic left ventricular dysfunction (starting 3–16 days after infarction) (under close medical Cardiovascular system supervision) ▶BY MOUTH ▶Adult: Initially 6.25 mg daily, then increased to 12.5 mg 3 times a day for 2 days, then increased if tolerated to 25 mg 3 times a day, then increased if tolerated to 75–150 mg daily in 2–3 divided doses, doses exceeding 75 mg per day to be increased gradually Diabetic nephropathy in type 1 diabetes mellitus ▶BY MOUTH ▶Adult: 75–100 mg daily in divided doses
Source pages 201, 202