Individual generic drug information
Extracted information for Carboplatin only.
Advanced ovarian cancer [epithelial origin] | Small cell lung cancer | High risk seminoma (stage I) testicular germ cell tumours [adjuvant treatment] ▶BY INTRAVENOUS INFUSION ▶Adult: (consult product literature)
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Carboplatin can be given in an outpatient setting.
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NICE decisions ▶Bevacizumab in combination with paclitaxel and carboplatin for the first-line treatment of advanced ovarian cancer (May 2013) NICE TA284 Bevacizumab in combination with paclitaxel and carboplatin is not recommended for the first-line treatment of advanced ovarian cancer (including fallopian tube and primary peritoneal cancer). Patients whose treatment was started before this guidance was published should have the option to continue treatment until they and their clinician consider it appropriate to stop. www.nice.org.uk/guidance/ta284 ▶Bevacizumab in combination with gemcitabine and carboplatin for treating the first recurrence of platinum- sensitive advanced ovarian cancer (May 2013) NICE TA285 Bevacizumab in combination with gemcitabine and carboplatin is not recommended within its marketing authorisation, that is, for the treatment of the first recurrence of platinum-sensitive advanced ovarian cancer (including fallopian tube and primary peritoneal cancer) that has not been previously treated with bevacizumab or other vascular endothelial growth factor (VEGF) inhibitors or VEGF receptor-targeted agents. Patients whose treatment was started before this guidance was published should have the option to continue treatment until they and their clinician consider it appropriate to stop. www.nice.org.uk/guidance/ta285
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Extracted information for Carboplatin only.
→Appendix 1: platinum compounds
Source page 994
▶Common or very common Alopecia. anaemia. asthenia. cardiovascular disorder. constipation. diarrhoea. gastrointestinal discomfort. haemorrhage. hypersensitivity. increased risk of infection. leucopenia. mucosal abnormalities. musculoskeletal disorder. nausea . neutropenia. ototoxicity. peripheral neuropathy. reflexes decreased. respiratory disorders. sensation abnormal. skin reactions. taste altered. thrombocytopenia. urogenital disorder. vision disorders. vomiting ▶Rare or very rare Angioedema ▶Frequency not known Appetite decreased. bone marrow failure. chills. dehydration. embolism. encephalopathy. extravasation necrosis. fever. haemolytic uraemic syndrome. heart failure. hypertension. hyponatraemia. hypotension. injection site necrosis. malaise. pancreatitis . stomatitis. stroke. treatment related secondary malignancy. tumour lysis syndrome
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Contraceptive advice required, see Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Avoid (teratogenic and embryotoxic in animal studies). See also Pregnancy and reproductive function in Cytotoxic drugs p. 938.
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Discontinue breast-feeding.
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Avoid if creatinine clearance less than 20 mL/minute. Dose adjustments Reduce dose. Monitoring Monitor haematological parameters in renal impairment. Monitor renal function in renal impairment.
Source page 994
Extracted information for Carboplatin only.
There can be variation in the licensing of different medicines containing the same drug. Solution for infusion ▶Carboplatin (Non-proprietary) Carboplatin 10 mg per 1 ml Carboplatin 50mg/5ml concentrate for solution for infusion vials | 1 vial P £20.20–£21.70 (Hospital only) Carboplatin 150mg/15ml concentrate for solution for infusion vials | 1 vial P £56.06–£60.59 (Hospital only) Carboplatin 600mg/60ml concentrate for solution for infusion vials | 1 vial P £232.64–£264.53 (Hospital only) Carboplatin 600mg/60ml solution for infusion vials | 1 vial P £260.00 (Hospital only) | 1 vial P £260.00 Carboplatin 450mg/45ml concentrate for solution for infusion vials | 1 vial P £166.32–£181.77 (Hospital only) Carboplatin 450mg/45ml solution for infusion vials | 1 vial P £197.48 (Hospital only) | 1 vial P £197.48 Carboplatin 150mg/15ml solution for infusion vials | 1 vial P £65.83 (Hospital only) | 1 vial P £65.83 Carboplatin 50mg/5ml solution for infusion vials | 1 vial P £22.86 (Hospital only) | 1 vial P £22.86
Source pages 994, 995
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
(consult product literature)
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 994
