Individual generic drug information
Extracted information for Caspofungin only.
Invasive aspergillosis | Invasive candidiasis | Empirical treatment of systemic fungal infections in patients with neutropenia ▶BY INTRAVENOUS INFUSION ▶Adult (body-weight up to 81 kg): 70 mg once daily for Infection 1 day, then 50 mg once daily ▶Adult (body-weight 81 kg and above): 70 mg once daily
Source page 650
DUE TO INTERACTIONS ▶Manufacturer advises increase dose to 70 mg daily with concurrent use of some enzyme inducers (such as carbamazepine, dexamethasone, phenytoin, and rifampicin); no dose adjustment required for patients already on 70 mg daily.
Source page 650
Extracted information for Caspofungin only.
→Appendix 1: caspofungin
Source page 650
▶Common or very common Arthralgia. diarrhoea. dyspnoea. electrolyte imbalance. fever. headache. hyperhidrosis. nausea. skin reactions. vomiting ▶Uncommon Anaemia. anxiety. appetite decreased. arrhythmias. ascites. chest discomfort. coagulation disorder. congestive heart failure. constipation. cough. disorientation. dizziness. drowsiness. dry mouth. dysphagia. excessive tearing. eyelid oedema. fatigue. flatulence. fluid overload. flushing. gastrointestinal discomfort. haematuria. hepatic disorders. hyperbilirubinaemia. hyperglycaemia. hypertension. hypotension. hypoxia. induration. insomnia. laryngeal pain. leucopenia. malaise. metabolic acidosis. muscle weakness. myalgia. nasal congestion. oedema. pain. palpitations. renal impairment. respiratory disorders. sensation abnormal. taste altered. thrombocytopenia. thrombophlebitis. tremor. vision blurred ▶Frequency not known Severe cutaneous adverse reactions (SCARs)
Source page 650
Manufacturer advises avoid unless essential—toxicity in animal studies.
Source page 650
Present in milk in animal studies— manufacturer advises avoid.
Source page 650
No information available for severe impairment. Dose adjustments 70 mg on first day then 35 mg once daily in moderate impairment.
Source page 650
Extracted information for Caspofungin only.
For intravenous infusion (Cancidas ®), give intermittently in Sodium chloride 0.9%. Allow vial to reach room temperature; initially reconstitute each vial with 10.5 mL water for injections, mixing gently to dissolve then dilute requisite dose in 250 mL infusion fluid (35- or 50-mg doses may be diluted in 100 ml infusion fluid if necessary); give over 60 minutes; incompatible with glucose solutions.
Source page 650
There can be variation in the licensing of different medicines containing the same drug. Powder for solution for infusion ▶Caspofungin (Non-proprietary) Caspofungin (as Caspofungin acetate) 50 mg Caspofungin 50mg powder for concentrate for solution for infusion vials | 1 vial P £50.25–£327.67 Caspofungin (as Caspofungin acetate) 70 mg Caspofungin 70mg powder for concentrate for solution for infusion vials | 1 vial P £52.91–£416.78 ▶Cancidas (Merck Sharp & Dohme Ltd) Caspofungin (as Caspofungin acetate) 50 mg Cancidas 50mg powder for solution for infusion vials | 1 vial P £327.67 Caspofungin (as Caspofungin acetate) 70 mg Cancidas 70mg powder for solution for infusion vials | 1 vial P £416.78
Source page 650
Filter the extracted dose blocks for this individual drug.
First line only; read the complete Indications and dose section above.
70 mg once daily for
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 650
First line only; read the complete Indications and dose section above.
70 mg once daily
This is a first-line fragment. Read the full Indications and Dose section above.
Candidate age grouping · source page 650
