Therapeutic Action
Third-generation cephalosporin antibacterial
Source page 375
Loading InternPractice…
Individual generic drug information
Extracted information for CEFOTAXIME only.
Third-generation cephalosporin antibacterial
Source page 375
In neonates: Bacterial meningitis, in combination with another antibacterial Urinary infection Pneumonia (ampicillin + gentamicin is preferred for this indication) Gonococcal conjunctivitis (if ceftriaxone is not available or contraindicated)
Source page 375
Extracted information for CEFOTAXIME only.
Do not administer to patients allergic to cephalosporins or penicillins (risk of cross-sensitivity). Administer with caution and reduce dosage in patients with renal impairment. Avoid or monitor combination with other nephrotoxic drugs: amphotericin B, aminoglycosides, pentamidine, etc. May cause: gastrointestinal disturbances (diarrhoea, nausea), haematological disorders (neutropenia, leucopenia), heart rhythm disorders if IV injection is too fast, allergic reactions and cutaneous reactions (Stevens-Johnson and Lyell syndromes), sometimes severe.
Source pages 375, 376
Extracted information for CEFOTAXIME only.
Powder for injection, in 250 mg and 500 mg vials, to be dissolved in 2 ml water for injection, for IM or slow IV injection (3 to 5 minutes) or IV infusion (20 to 60 minutes) in 0.9% sodium chloride or 5% glucose.
Source page 375
Meningitis, urinary infection, pneumonia 0 to 7 days (< 2 kg): 50 mg/kg every 12 hours 0 to 7 days (≥ 2 kg): 50 mg/kg every 8 hours 8 days to < 1 month: 50 mg/kg every 8 hours Gonococcal conjunctivitis 100 mg/kg IM single dose For IV administration, cefotaxime powder can only be dissolved in water for injection. For infusions, each dose of cefotaxime must be dissolved in 5 ml/kg of 0.9% sodium chloride or 5% glucose.
Source page 375
Depending on indication and clinical response
Source page 375
Extracted information for CEFOTAXIME only.
Do not mix with other drugs in the same syringe or bottle.
Source page 376
– – Below 25 °C Once reconstituted, the solution must be used immediately.
Source page 376
Filter the extracted dose blocks for this individual drug.