Individual generic drug information

cefotaxime

Reference monograph

Part of registered formulation

CEFOTAXIME

Reference record: Cefotaxime
Source: BNF 80 (2020–2021)
Printed source pages: 577
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Cefotaxime only.

Indications And Dose

Uncomplicated gonorrhoea ▶BY INTRAMUSCULAR INJECTION ▶Adult: 500 mg for 1 dose Infections due to sensitive Gram-positive and Gram- negative bacteria | Surgical prophylaxis | Haemophilus epiglottitis ▶BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 1 g every 12 hours Severe susceptible infections due to sensitive Gram- positive and Gram-negative bacteria | Meningitis ▶BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION ▶Adult: 8 g daily in 4 divided doses, increased if necessary to 12 g daily in 3–4 divided doses, intramuscular doses over 1 g should be divided between more than one site Emergency treatment of suspected bacterial meningitis or meningococcal disease, before urgent transfer to hospital, in patients who cannot be given benzylpenicillin (e.g. because of an allergy) ▶BY INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION ▶Child 1 month–11 years: 50 mg/kg for 1 dose ▶Child 12–17 years: 1 g for 1 dose Infection ▶Adult: 1 g for 1 dose

Source page 577

Safety

Extracted information for Cefotaxime only.

Interactions

→Appendix 1: cephalosporins

Source page 577

Side Effects

▶Uncommon Drug fever. Jarisch-Herxheimer reaction. renal impairment. seizure ▶Frequency not known Arrhythmia (following rapid injection). bronchospasm. encephalopathy. fungal infection. hepatic disorders

Source page 577

Pregnancy

Not known to be harmful.

Source page 577

Breast Feeding

Present in milk in low concentration, but appropriate to use.

Source page 577

Renal Impairment

Dose adjustments ▶In adults If eGFR less than 5 mL/minute/1.73 m2, initial dose of 1 g then use half normal dose. ▶In children Usual initial dose, then use half normal dose if estimated glomerular ﬁltration rate less than 5 mL/minute/1.73 m2.

Source page 577

Dose and formulations

Extracted information for Cefotaxime only.

Directions For Administration

▶With intravenous use in children Displacement value may be signiﬁcant, consult local guidelines. For intermittent intravenous infusion dilute in glucose 5% or sodium chloride 0.9%; administer over 20–60 minutes; incompatible with alkaline solutions. ▶With intravenous use in adults For intravenous infusion, give intermittently in Glucose 5% or Sodium chloride 0.9%. Suggested volume 40–100 mL given over 20–60 minutes; incompatible with alkaline solutions.

Source page 577

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Powder for solution for injection ▶Cefotaxime (Non-proprietary) Cefotaxime (as Cefotaxime sodium) 500 mg Cefotaxime 500mg powder for solution for injection vials | 10 vial P £30.00 | 10 vial P £21.00 (Hospital only) Cefotaxime (as Cefotaxime sodium) 1 gram Cefotaxime 1g powder for solution for injection vials | 10 vial P £35.00 | 10 vial P £42.00 (Hospital only) Cefotaxime (as Cefotaxime sodium) 2 gram Cefotaxime 2g powder for solution for injection vials | 10 vial P £37.50 eiiii F 550

Source page 577

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Adults

First line only; read the complete Indications and dose section above.

1 g every 12 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Adults

First line only; read the complete Indications and dose section above.

8 g daily in 4 divided doses, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Children

First line only; read the complete Indications and dose section above.

50 mg/kg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Children

First line only; read the complete Indications and dose section above.

1 g for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Adults

First line only; read the complete Indications and dose section above.

1 g for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

cefotaxime

Reference monograph

Part of registered formulation

CEFOTAXIME

Reference record: Cefotaxime
Source: BNF 80 (2020–2021)
Printed source pages: 577
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Cefotaxime only.

Indications And Dose

Source page 577

Safety

Extracted information for Cefotaxime only.

Interactions

→Appendix 1: cephalosporins

Source page 577

Side Effects

Source page 577

Pregnancy

Not known to be harmful.

Source page 577

Breast Feeding

Present in milk in low concentration, but appropriate to use.

Source page 577

Renal Impairment

Source page 577

Dose and formulations

Extracted information for Cefotaxime only.

Directions For Administration

Source page 577

Medicinal Forms

Source page 577

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Adults

First line only; read the complete Indications and dose section above.

1 g every 12 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Adults

First line only; read the complete Indications and dose section above.

8 g daily in 4 divided doses, increased if

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Children

First line only; read the complete Indications and dose section above.

50 mg/kg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Children

First line only; read the complete Indications and dose section above.

1 g for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Adults

First line only; read the complete Indications and dose section above.

1 g for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 577

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.