Indications And Dose
Active rheumatoid arthritis (administered on expert advice) | Systemic and discoid lupus erythematosus (administered on expert advice) ▶BY MOUTH USING TABLETS ▶Adult: 155 mg daily; maximum 2.5 mg/kg per day Prophylaxis of malaria ▶INITIALLY BY MOUTH USING SYRUP ▶Child 4–5 weeks (body-weight up to 4.5 kg): 25 mg once weekly, started 1 week before entering endemic area and continued for 4 weeks after leaving ▶Child 6 weeks–5 months (body-weight 4.5–7 kg): 50 mg once weekly, started 1 week before entering endemic area and continued for 4 weeks after leaving ▶Child 6–11 months (body-weight 8–10 kg): 75 mg once weekly, started 1 week before entering endemic area continued → and continued for 4 weeks after leaving ▶Child 1–2 years (body-weight 11–14 kg): 100 mg once weekly, started 1 week before entering endemic area and continued for 4 weeks after leaving ▶Child 3–4 years (body-weight 15–16.4 kg): 125 mg once weekly, started 1 week before entering endemic area and continued for 4 weeks after leaving ▶Child 5–7 years (body-weight 16.5–24 kg): 150 mg once weekly, alternatively (by mouth using tablets) 155 mg once weekly, started 1 week before entering endemic Infection area and continued for 4 weeks after leaving ▶Child 8–13 years (body-weight 25–44 kg): 225 mg once weekly, alternatively (by mouth using tablets) 232.5 mg once weekly, started 1 week before entering endemic area and continued for 4 weeks after leaving ▶INITIALLY BY MOUTH USING TABLETS ▶Child 14–17 years (body-weight 45 kg and above): 310 mg once weekly, alternatively (by mouth using syrup) 300 mg once weekly, started 1 week before entering endemic area and continued for 4 weeks after leaving ▶Adult (body-weight 45 kg and above): 310 mg once weekly, alternatively (by mouth using syrup) 300 mg once weekly, started 1 week before entering endemic area and continued for 4 weeks after leaving Treatment of non-falciparum malaria ▶BY MOUTH ▶Child: Initially 10 mg/kg (max. per dose 620 mg), then 5 mg/kg after 6–8 hours (max. per dose 310 mg), then 5 mg/kg daily (max. per dose 310 mg) for 2 days ▶Adult: Initially 620 mg, then 310 mg after 6–8 hours, then 310 mg daily for 2 days, approximate total cumulative dose of 25 mg/kg of base P. vivax or P. ovale infection during pregnancy while radical cure is postponed ▶BY MOUTH ▶Adult: 310 mg once weekly DOSE EQUIVALENCE AND CONVERSION ▶Doses expressed as chloroquine base. ▶Each tablet contains 155 mg of chloroquine base (equivalent to 250 mg of chloroquine phosphate). Syrup contains 50 mg/5 mL of chloroquine base (equivalent to 80 mg/5 mL of chloroquine phosphate). DOSES AT EXTREMES OF BODY-WEIGHT ▶With oral use in adults In active rheumatoid arthritis and systemic and discoid lupus erythematosus, to avoid excessive dosage in obese patients, the daily maximum dose should be calculated on the basis of ideal body weight. l UNLICENSED USE Chloroquine doses for the treatment and prophylaxis of malaria in BNF publications may differ from those in product literature.
Source pages 673, 674