Indications And Dose
Benign duodenal ulceration ▶BY MOUTH ▶Adult: 400 mg twice daily for at least 4 weeks, to be taken with breakfast and at night, alternatively 800 mg once daily for at least 4 weeks, to be taken at night; increased if necessary up to 400 mg 4 times a day; maintenance 400 mg once daily, to be taken at night, alternatively maintenance 400 mg twice daily, to be taken in the morning and at night Benign gastric ulceration ▶BY MOUTH ▶Adult: 400 mg twice daily for 6 weeks, to be taken with breakfast and at night, alternatively 800 mg daily for 6 weeks, to be taken at night; increased if necessary up to 400 mg 4 times a day; maintenance 400 mg once daily, to be taken at night, alternatively maintenance 400 mg twice daily, to be taken in the morning and at night NSAID-associated ulceration ▶BY MOUTH ▶Adult: 400 mg twice daily for 8 weeks, to be taken with breakfast and at night, alternatively 800 mg daily for 8 weeks, to be taken at night; increased if necessary up to 400 mg 4 times a day; maintenance 400 mg daily, to be taken at night, alternatively maintenance 400 mg twice daily, to be taken in the morning and at night Reflux oesophagitis ▶BY MOUTH ▶Adult: 400 mg 4 times a day for 4–8 weeks Prophylaxis of stress ulceration ▶BY MOUTH ▶Adult: 200–400 mg every 4–6 hours Gastric acid reduction in obstetrics ▶BY MOUTH ▶Adult: Initially 400 mg, to be administered at start of labour, then increased if necessary up to 400 mg every 4 hours, do not use syrup in prophylaxis of acid aspiration; maximum 2.4 g per day Gastric acid reduction during surgical procedures ▶BY MOUTH ▶Adult: 400 mg, to be given 90–120 minutes before induction of general anaesthesia Short-bowel syndrome ▶BY MOUTH ▶Adult: 400 mg twice daily, adjusted according to response, to be taken with breakfast and at bedtime To reduce degradation of pancreatic enzyme supplements ▶BY MOUTH ▶Adult: 0.8–1.6 g daily in 4 divided doses, dose to be taken 1–1½ hours before meals
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