Individual generic drug information

ciprofloxacin

Reference monograph

Part of registered formulation

CIPROFLOXACIN

Reference record: Ciprofloxacin
Source: BNF 80 (2020–2021)
Printed source pages: 612, 613, 614
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Ciprofloxacin only.

Indications And Dose

Moderate diabetic foot infection | Severe diabetic foot infection ▶BY MOUTH ▶Adult: 500 mg twice daily ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 8–12 hours, to be given over 60 minutes Fistulating Crohn’s disease ▶BY MOUTH ▶Adult: 500 mg twice daily Acute diverticulitis [in combination with metronidazole] (administered on expert advice) ▶BY MOUTH ▶Adult: 500 mg twice daily for 5 days then review ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 8–12 hours, to be given over 60 minutes Respiratory-tract infections ▶BY MOUTH ▶Adult: 500–750 mg twice daily ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 8–12 hours, to be given over 60 minutes Pseudomonal lower respiratory-tract infection in cystic fibrosis ▶BY MOUTH ▶Adult: 750 mg twice daily Urinary-tract infections ▶BY MOUTH ▶Adult: 250–750 mg twice daily ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 8–12 hours, to be given over 60 minutes Acute prostatitis ▶BY MOUTH ▶Adult: 500 mg twice daily for 14 days then carry out a clinical assessment to decide whether to continue for a further 14 days ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 8–12 hours Gonorrhoea ▶BY MOUTH ▶Adult: 500 mg for 1 dose Most other infections ▶BY MOUTH ▶Adult: Initially 500 mg twice daily; increased to 750 mg twice daily, in severe or deep-seated infection ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 8–12 hours, to be given over 60 minutes Surgical prophylaxis ▶BY MOUTH ▶Adult: 750 mg, to be taken 60 minutes before procedure Anthrax (treatment and post-exposure prophylaxis) ▶BY MOUTH ▶Adult: 500 mg twice daily ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 12 hours, to be given over 60 minutes Prevention of secondary case of meningococcal meningitis ▶BY MOUTH ▶Child 1 month–4 years: 30 mg/kg (max. per dose 125 mg) for 1 dose ▶Child 5–11 years: 250 mg for 1 dose ▶Child 12–17 years: 500 mg for 1 dose ▶Adult: 500 mg for 1 dose Acute pyelonephritis | Urinary tract infection (catheter- associated) ▶BY MOUTH ▶Adult: 500 mg twice daily for 7 days ▶BY INTRAVENOUS INFUSION ▶Adult: 400 mg every 8–12 hours l UNLICENSED USE Not licensed for use in children for prophylaxis of meningococcal meningitis.

Source pages 612, 613

Cautions

Acute myocardial infarction (risk factor for QT interval prolongation). avoid excessive alkalinity of urine (risk of crystalluria). bradycardia (risk factor for QT interval prolongation). congenital long QT syndrome (risk factor for QT interval prolongation). electrolyte disturbances (risk factor for QT interval prolongation). ensure adequate ﬂuid intake (risk of crystalluria). heart failure with reduced left ventricular ejection fraction (risk factor for QT interval prolongation). history of symptomatic arrhythmias (risk factor for QT interval prolongation)

Source page 613

Prescribing And Dispensing Information

For choice of antibacterial therapy, see Antibacterials, use for prophylaxis p. 529, Anthrax p. 609, Diabetic foot infections, antibacterial therapy p. 533, Ear infections, antibacterial therapy p. 534, Eye, infections p. 1234, Gastro-intestinal system infections, antibacterial therapy p. 535, Genital system infections, antibacterial therapy p. 536, Respiratory system infections, antibacterial therapy p. 538, Urinary-tract infections p. 622.

Source page 613

Safety

Extracted information for Ciprofloxacin only.

Interactions

→Appendix 1: quinolones

Source page 613

Side Effects

▶Common or very common Arthropathy (in children) ▶Rare or very rare Bone marrow depression. crystalluria. erythema nodosum. haematuria. intracranial pressure increased. leucocytosis. migraine. muscle tone increased. status epilepticus ▶Frequency not known Mood altered

Source page 613

Pregnancy

A single dose of ciproﬂoxacin may be used for the prevention of a secondary case of meningococcal meningitis.

Source page 613

Breast Feeding

Amount too small to be harmful but manufacturer advises avoid.

Source page 613

Renal Impairment

Dose adjustments ▶With oral use in adults Give 250–500 mg Infection every 12 hours if eGFR 30–60 mL/minute/1.73 m2 (every 24 hours if eGFR less than 30 mL/minute/1.73 m2). ▶With intravenous use in adults Give (200 mg over 30 minutes), 200–400 mg every 12 hours if eGFR 30–60 mL/minute/1.73m2 (every 24 hours if eGFR less than 30 mL/minute/1.73 m2). ▶In children Reduce dose if estimated glomerular ﬁltration rate less than 30 mL/minute/1.73 m2—consult product literature.

Source page 613

Dose and formulations

Extracted information for Ciprofloxacin only.

Medicinal Forms

There can be variation in the licensing of different medicines containing the same drug. Forms available from special-order manufacturers include: oral suspension Tablet CAUTIONARY AND ADVISORY LABELS 7, 9, 25 ▶Ciprofloxacin (Non-proprietary) Ciprofloxacin (as Ciprofloxacin hydrochloride) 100 mg Ciprofloxacin 100mg tablets | 6 tablet P £4.50 DT = £2.11 Ciprofloxacin (as Ciprofloxacin hydrochloride) 250 mg Ciprofloxacin 250mg tablets | 10 tablet P £7.21 DT = £0.79 | 20 tablet P £1.39–£14.42 | 100 tablet P £7.90 Ciprofloxacin (as Ciprofloxacin hydrochloride) 500 mg Ciprofloxacin 500mg tablets | 10 tablet P £12.49 DT = £1.05 | 20 tablet P £1.56–£27.29 | 100 tablet P £9.10 Ciprofloxacin (as Ciprofloxacin hydrochloride) 750 mg Ciprofloxacin 750mg tablets | 10 tablet P £17.78 DT = £8.00 | 20 tablet P £15.99 ▶Ciproxin (Bayer Plc) Ciprofloxacin (as Ciprofloxacin hydrochloride) 500 mg Ciproxin 500mg tablets | 10 tablet P £12.49 DT = £1.05 Oral suspension CAUTIONARY AND ADVISORY LABELS 7, 9, 25 ▶Ciproxin (Bayer Plc) Ciprofloxacin 50 mg per 1 ml Ciproxin 250mg/5ml oral suspension | 100 ml P £21.29 DT = £21.29 Solution for infusion ELECTROLYTES: May contain Sodium ▶Ciprofloxacin (Non-proprietary) Ciprofloxacin (as Ciprofloxacin lactate) 2 mg per 1 ml Ciprofloxacin 200mg/100ml solution for infusion vials | 1 vial P £10.00 Ciprofloxacin 200mg/100ml solution for infusion bottles | 10 bottle P £131.00–£144.50 Ciprofloxacin 100mg/50ml solution for infusion vials | 1 vial P £10.00–£13.00 Ciprofloxacin 400mg/200ml solution for infusion bottles | 1 bottle P £10.00 | 10 bottle P £195.90–£199.20 Ciprofloxacin 400mg/200ml solution for infusion vials | 1 vial P £10.00 ▶Ciproxin (Bayer Plc) Ciprofloxacin (as Ciprofloxacin lactate) 2 mg per 1 ml Ciproxin 100mg/50ml solution for infusion bottles | 1 bottle P £7.61 (Hospital only) Ciproxin 200mg/100ml solution for infusion bottles | 1 bottle P £15.01 (Hospital only) | 5 bottle P £75.06 (Hospital only) Ciproxin 400mg/200ml solution for infusion bottles | 1 bottle P £22.85 (Hospital only) | 5 bottle P £114.23 (Hospital only) Infusion Infection ▶Ciprofloxacin (Non-proprietary) Ciprofloxacin (as Ciprofloxacin lactate) 2 mg per 1 ml Ciprofloxacin 200mg/100ml infusion bags | 5 bag P £60.00 (Hospital only) | 10 bag P £120.00 (Hospital only) Ciprofloxacin 400mg/200ml infusion bags | 5 bag P £85.00 (Hospital only) | 10 bag P £170.00–£228.46 (Hospital only) eiiii F 589

Source pages 613, 614

Clinical care

Extracted information for Ciprofloxacin only.

Patient And Carer Advice

Medicines for Children leaflet: Ciprofloxacin for bacterial infections www.medicinesforchildren.org.uk/ciprofloxacin-bacterial- infection Driving and skilled tasks May impair performance of skilled tasks (e.g. driving); effects enhanced by alcohol.

Source page 613

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 5 days then review

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

500–750 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

750 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

250–750 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 14 days then carry out a

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

Initially 500 mg twice daily; increased to 750 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

750 mg, to be taken 60 minutes before procedure

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Children

First line only; read the complete Indications and dose section above.

30 mg/kg (max. per dose 125 mg)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Children

First line only; read the complete Indications and dose section above.

250 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Children

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 7 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.

Individual generic drug information

ciprofloxacin

Reference monograph

Part of registered formulation

CIPROFLOXACIN

Reference record: Ciprofloxacin
Source: BNF 80 (2020–2021)
Printed source pages: 612, 613, 614
Age groups indexed: 2

Individual active ingredientSource records are displayed separately

Some source sections could not be separated reliably in the extraction. Review the printed source pages when a field is missing or incomplete.

Overview

Extracted information for Ciprofloxacin only.

Indications And Dose

Source pages 612, 613

Cautions

Source page 613

Prescribing And Dispensing Information

Source page 613

Safety

Extracted information for Ciprofloxacin only.

Interactions

→Appendix 1: quinolones

Source page 613

Side Effects

Source page 613

Pregnancy

A single dose of ciproﬂoxacin may be used for the prevention of a secondary case of meningococcal meningitis.

Source page 613

Breast Feeding

Amount too small to be harmful but manufacturer advises avoid.

Source page 613

Renal Impairment

Source page 613

Dose and formulations

Extracted information for Ciprofloxacin only.

Medicinal Forms

Source pages 613, 614

Clinical care

Extracted information for Ciprofloxacin only.

Patient And Carer Advice

Source page 613

Dose text by age group

Filter the extracted dose blocks for this individual drug.

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 5 days then review

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

500–750 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 612

Adults

First line only; read the complete Indications and dose section above.

750 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

250–750 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 14 days then carry out a

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

Initially 500 mg twice daily; increased to 750 mg

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

750 mg, to be taken 60 minutes before procedure

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 12 hours, to be given over

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Children

First line only; read the complete Indications and dose section above.

30 mg/kg (max. per dose 125 mg)

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Children

First line only; read the complete Indications and dose section above.

250 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Children

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg for 1 dose

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

500 mg twice daily for 7 days

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Adults

First line only; read the complete Indications and dose section above.

400 mg every 8–12 hours

This is a first-line fragment. Read the full Indications and Dose section above.

Candidate age grouping · source page 613

Age labels are extracted from the printed dose headings and require clinical review. Confirm current local guidance, dose, route, formulation, contraindications and interactions before prescribing.