Indications And Dose
Mild diabetic foot infection ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 500 mg twice daily for 7 days then review Leg ulcer infection ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 500 mg twice daily for 7 days Cellulitis | Erysipelas ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 5–7 days then review (review after 7 days if infection near the eyes or nose) ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 5–7 days then review (review after 7 days if infection near the eyes or nose) ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 5–7 days then review (review after 7 days if infection near the eyes or nose) ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 5–7 days then review (review after 7 days if infection near the eyes or nose) ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 5–7 days then review (review after 7 days if infection near the eyes or nose) ▶Child 12–17 years: 250–500 mg twice daily for 5–7 days then review (review after 7 days if infection near the eyes or nose) ▶Adult: 500 mg twice daily for 5–7 days then review (review after 7 days if infection near the eyes or nose) ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 12 hours Impetigo ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 5–7 days ▶Child 12–17 years: 250 mg twice daily for 5–7 days, increased if necessary to 500 mg twice daily, increased dose used in severe infections ▶Adult: 250 mg twice daily for 5–7 days, increased if necessary to 500 mg twice daily, increased dose used in severe infections Community-acquired pneumonia ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 5 days ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 5 days Infection ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 5 days ▶Child 12–17 years: 250–500 mg twice daily for 5 days ▶Adult: 500 mg twice daily for 5 days ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 12 hours Hospital-acquired pneumonia ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 5 days then review ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 5 days then review ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 5 days then review ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 5 days then review ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 5 days then review ▶Child 12–17 years: 500 mg twice daily for 5 days then review Respiratory-tract infections | Mild to moderate skin and soft-tissue infections ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily ▶Child 12–17 years: 250 mg twice daily usually for 7–14 days, increased to 500 mg twice daily, if required in severe infections ▶Adult: 250 mg twice daily usually for 7–14 days, increased to 500 mg twice daily, if required in severe infections ▶BY MOUTH USING MODIFIED-RELEASE MEDICINES ▶Child 12–17 years: 500 mg once daily usually for 7–14 days, increased to 1 g once daily, if required in severe infections ▶Adult: 500 mg once daily usually for 7–14 days, increased to 1 g once daily, if required in severe infections ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 12 hours maximum duration 5 days, switch to oral route when appropriate, to be administered into a large proximal vein Acute exacerbation of chronic obstructive pulmonary disease ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Adult: 500 mg twice daily for 5 days ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 12 hours, to be administered into a large proximal vein Acute exacerbation of bronchiectasis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg continued → twice daily for 7–14 days ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 7–14 days ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 7–14 days ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 7–14 days ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 7–14 days ▶Child 12–17 years: 250–500 mg twice daily for 7–14 days Infection ▶Adult: 500 mg twice daily for 7–14 days Acute cough [if systemically very unwell or at higher risk of complications] | Acute sore throat ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 5 days ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 5 days ▶Child 12–17 years: 250–500 mg twice daily for 5 days ▶Adult: 250–500 mg twice daily for 5 days Acute otitis media ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 5–7 days ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 5–7 days ▶Child 12–17 years: 250–500 mg twice daily for 5–7 days ▶Adult: 250 mg twice daily usually for 7–14 days, increased to 500 mg twice daily, if required in severe infections ▶BY INTRAVENOUS INFUSION ▶Adult: 500 mg every 12 hours maximum duration 5 days, switch to oral route when appropriate, to be administered into a large proximal vein Prevention of pertussis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 7 days ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 7 days ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 7 days ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 7 days ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 7 days ▶Child 12–17 years: 500 mg twice daily for 7 days ▶Adult: 500 mg twice daily for 7 days Helicobacter pylori eradication [in combination with other drugs (see Helicobacter pylori infection p. 89)] ▶BY MOUTH ▶Adult: 500 mg twice daily for 7 days for first- and second-line eradication therapy; 10 days for third-line eradication therapy Acute sinusitis ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 1 month–11 years (body-weight up to 8 kg): 7.5 mg/kg twice daily for 5 days ▶Child 1 month–11 years (body-weight 8–11 kg): 62.5 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 12–19 kg): 125 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 20–29 kg): 187.5 mg twice daily for 5 days ▶Child 1 month–11 years (body-weight 30–40 kg): 250 mg twice daily for 5 days ▶Child 12–17 years: 250 mg twice daily for 5 days, alternatively 500 mg twice daily for 5 days ▶Adult: 500 mg twice daily for 5 days l UNLICENSED USE g Duration of treatment for acute sinusitis differs from product literature and adheres to national guidelines. h ▶With oral use in children g Duration of treatment for acute otitis media differs from product literature and adheres to national guidelines. h Tablets not licensed for use in children under 12 years; oral suspension not licensed for use in infants under 6 months. ▶In adults g Combination regimens and durations for Helicobacter pylori eradication may differ from product literature but adhere to national guidelines. h
Source pages 589, 590